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Occupational Exposures Linked to Interstitial Lung Disease

Job exposure matrix score increase in vapors, gas, dust, fumes exposure ups high attenuation areas
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Pulmonology, Journal, Source Type: news

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Authors: Kiriu T, Tamura D, Tachihara M, Sekiya R, Hazama D, Katsurada M, Nakata K, Nagano T, Yamamoto M, Kamiryo H, Kobayashi K, Nishimura Y Abstract A 62-year-old male with lung adenocarcinoma harboring an exon 19 deletion in the EGFR was treated with EGFR-TKIs and several cytotoxic agents. After administering a fifth-line chemotherapy regimen, a liver biopsy revealed a diagnosis of recurrence with a T790M mutation. After an 82-day course of osimertinib therapy, the patient developed osimertinib-induced interstitial lung disease (ILD). Osimertinib was discontinued, and oral prednisolone was started. The ILD quick...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusions: In our patients, pulmonary involvement was more common than cardiac involvement. Interstitial lung disease and cardiac involvement were more commonly seen in diffuse systemic sclerosis whereas pulmonary hypertension was more frequent in limited systemic sclerosis. Hence, it is important to screen the patients for cardiopulmonary involvement for early diagnosis and treatment and a better prognostic outcome.
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research
ConclusionsIn this sample of patients with IPF and sarcoidosis, obstructive sleep apnea is common at least in a mild degree of severity. The SF-36 questionnaire may be a useful tool for the evaluation of the quality of life in these patients.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
PMID: 29028374 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Publication date: Available online 13 October 2017 Source:The Lancet Respiratory Medicine Author(s): Michael Kreuter, Elisabeth Bendstrup, Anne-Marie Russell, Sabrina Bajwah, Kathleen Lindell, Yochai Adir, Crystal E Brown, Greg Calligaro, Nicola Cassidy, Tamera J Corte, Klaus Geissler, Azza Adel Hassan, Kerri A Johannson, Ronaldo Kairalla, Martin Kolb, Yasuhiro Kondoh, Sylvia Quadrelli, Jeff Swigris, Zarir Udwadia, Athol Wells, Marlies Wijsenbeek Progressive fibrotic interstitial lung diseases (ILDs) are characterised by major reductions in quality of life and survival and have similarities to certain malignancies. Howeve...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
AbstractThe use of hydroxychloroquine (HCQ) in Primary Sj ögren’s Syndrome (pSS) has been assessed in different studies over the last years, with conflicting results regarding its efficacy in sicca syndrome and extraglandular manifestations (EGM). The goal of this study was to compare the incidence rate of EGM in pSS patients with and without HCQ therap y.We performed a multicenter retrospective study, including patients with pSS (European classification criteria) with at least 1  year of follow-up. Subjects with concomitant fibromyalgia, autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosi...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Summary Autoantibodies to melanoma differentiation‐associated protein 5 (MDA5) are associated with a subset of patients with dermatomyositis (DM) who have rapidly progressive interstitial lung disease (RP‐ILD) with poor prognosis. Intensive immunosuppressive therapy is initiated before irreversible lung damage can occur; however, there are few lines of evidence for the treatment of RP‐ILD. Here, we report three cases of anti‐MDA5 antibody‐associated DM with RP‐ILD in which the patients were treated with combined‐modality therapy, including high‐dose prednisolone, tacrolimus, intravenous cyclophosphamide and...
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Case report: Therapy Source Type: research
RadioGraphics,Volume 37, Issue 6, Page 1679-1703, October 2017.
Source: Radiographics - Category: Radiology Authors: Source Type: research
Purpose of review: To provide the most recent evidence on anti-Jo-1 syndrome. Recent findings: Several new evidences on anti-Jo-1 syndrome have recently emerged. It has been clearly established that, at disease onset, the classic clinical triad (arthritis, myositis and interstitial lung disease – ILD) is only rarely observed. Indeed, disease onset with an isolated arthritis is common. Patients presenting with an isolated manifestation are at high risk for the subsequent occurrence of initially lacking triad findings. Moreover, the ex-novo occurrence of accompanying features such as Raynaud's phenomenon, mechanic's h...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: MYOSITIS AND MYOPATHIES: Edited by Ingrid E. Lundberg and Jiri Vencovsky Source Type: research
Conclusions: Pneumonia, bronchiectasis, and interstitial lung disease were the most common abnormalities seen in RA patients. The presence of comorbidity, male gender, and ExRA was significantly associated with lung involvement.
Source: Annals of Thoracic Medicine - Category: Respiratory Medicine Authors: Source Type: research
More News: Interstitial Lung Disease | Occupational Health | Respiratory Medicine