Loss of phosphodiesterase 4 in Parkinson disease: Relevance to cognitive deficits

Conclusions:
Our findings demonstrate loss of PDE4 expression in the striato-thalamo-cortical circuit, which is associated with deficits of spatial working memory in patients with PD.

Source: Neurology - August 7, 2017 Category: Neurology Authors: Niccolini, F., Wilson, H., Pagano, G., Coello, C., Mehta, M. A., Searle, G. E., Gunn, R. N., Rabiner, E. A., Foltynie, T., Politis, M. Tags: MRI, PET, Volumetric MRI, Parkinson's disease/Parkinsonism, Parkinson's disease with dementia ARTICLE Source Type: research