Behavioral-variant frontotemporal dementia: Distinct phenotypes with unique functional profiles

Conclusions: This study reveals that different clinical behavioral phenotypes of bvFTD have differing profiles of functional decline and distinct patterns of associated cortical changes. These findings emphasize the importance of apathy in functional impairment, highlight the role of the right temporal region in disinhibition, and suggest that disability may be a sensitive outcome measure for treatments targeting reduction of apathy. These phenotypes could also support understanding of prognosis and clinical management.
Source: Neurology - Category: Neurology Authors: Tags: MRI, Frontotemporal dementia ARTICLE Source Type: research