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Increased brain acidity in psychiatric disorders

(Fujita Health University) Decreased brain pH in the patients with schizophrenia and bipolar disorder has been considered to be the result of secondary factors associated with the diseases, such as medication and agonal state. However, the researchers of the present study suggest that decreased brain pH is a primary feature of the diseases themselves, based on the current findings from systematic investigation using five animal models, which are devoid of such secondary factors.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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In this study, we propose an alternate approach, known as gray matter surface based spatial statistics (GS-BSS), to perform statistical analysis using gray matter surfaces by incorporating established methods of registration techniques of GM surface segmentation on structural images. Diffusion microstructure features from NODDI and GM surfaces are transferred to standard space. All the surfaces are then projected onto a common GM surface non-linearly using diffeomorphic spectral matching on cortical surfaces. Prior post-mortem studies have shown reduced dendritic length in prefrontal cortex region in schizophrenia and bipo...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
BACKGROUND: Childhood trauma has long-term adverse effects on physical and psychological health. Previous studies demonstrated that suicide and mental disorders were related to childhood trauma. In China, there is insufficient research available on childho...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
(University of California - San Diego) Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer's, Parkinson's, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered which of these subtypes are most susceptible to common risk factors for different brain diseases.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSION: The rates of disorder prevalence observed indicates a need for continued awareness of mental health difficulties, particularly substance and alcohol use disorders, in older veterans. In the future studies with non-U.S. military samples using a longitudinal design are required to further understand the prevalence of mental health disorders in geriatric veterans. PMID: 29221697 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
In almost 6800 patients with psychosis that was induced by any substance, 32% converted to either schizophrenia or bipolar disorder; 47% converted after cannabis-induced psychosis.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
Conclusion: Our findings showed no association between BDV infection and pathogenesis of these psychiatric disorders. This is an interesting issue given both the as yet un-clarified role of BDV in human mental disorders and addressing patients in the so far under-investigating Middle East era. PMID: 29214003 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
Conclusions: Psychiatric conditions are related to more difficulties to stop smoking and these patients have a tendency to a better response to low doses.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tobacco, Smoking Control and Health Education Source Type: research
We examined whether electroconvulsive therapy (ECT) plus medications (“STABLE + PHARM” group) had superior HRQOL compared with medications alone (“PHARM” group) as continuation strategy after successful acute right unilateral ECT for major depressive disorder (MDD). We hypothesized that scores from the Medical Outcomes Study Short Form-36 (SF-36) would be higher during continuation treatment in the “STABLE + PHARM” group versus the “PHARM” group. The overall study design was called “Prolonging Remission in Depressed Elderly” (PRIDE). Remitters ...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
One of my readers, Natalie, wondered about my thoughts about the digital pill. My initial reactions were similar to several of those who were interviewed for the article. The digital pill, which provides electronic information to confirm whether someone has ingested the medication, has great potential to become a tool of coercion. Aripiprazole (Abilify) is classified as an antipsychotic medication, which is often prescribed to people who have beliefs that machines and other surveillance tools are in their bodies. Why would the nascent technology of a digital pill make its debut for this population? I have se...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Tech Medications Psychiatry Source Type: blogs
ConclusionsThese results indicate that the genetic overlap between alcohol misuse and BD is significantly moderated by trauma exposure. This provides molecular insight into the complex mechanisms that link substance abuse, psychiatric disorders, and trauma exposure.
Source: Acta Psychiatrica Scandinavica - Category: Psychiatry Authors: Tags: Original article Source Type: research
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