Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS)

Conclusions: The LEnS concept is a practical refinement to the exposome that accounts for total exposures during particular windows of susceptibility in target organ systems. Application of the LEnS framework in risk assessment and regulation will improve protection of children’s health by enhancing protection of sensitive developing organ systems that are critical for lifelong health and well-being. https://doi.org/10.1289/EHP1250 Received: 19 October 2016 Revised: 08 March 2017 Accepted: 04 April 2017 Published: 07 August 2017 Please address correspondence to E.M. Faustman, Dept. of Environmental and Occupational Health Sciences, 4225 Roosevelt Way NE, Suite 100, University of Washington, Seattle, WA 98105 USA. Telephone: (206) 685-2269. Email: faustman@u.washington.edu The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Introduction The development of the concept of the exposome (Wild 2005) has provided the field of environmental health with the...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research

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Notch signaling is a highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeostasis. Dysregulated Notch signaling has also been implicated in human disease, including multiple forms of cancer, and represents an emerging therapeutic target. Successful development of such therapeutics requires a detailed understanding of potential on-target toxicities. Here, we identify autosomal dominant mutations of the canonical Notch ligand Jagged1 (or JAG1) as a cause of peripheral nerve disease in 2 unrelated families with the hereditary axonal neuropathy Charcot-Marie-T...
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The long-term health risks associated with e-cigs are not fully known and following a recent outbreak of lung illness within the United States of America which has accounted for over 2,000 illnesses and 40 deaths, the American Medical Association have ...
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Adolescence is a key window of vulnerability for depression, the leading cause of disability worldwide. The prevention of depression among young people is therefore of substantial public health importance. A growing body of large-scale data now support...
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Some epileptic spasms are classified into focal-onset seizures. However, the cortical network underlying this kind of spasm seizure is not yet clear. Four patients with epileptic spasms who underwent intracranial electrode implantation and focal resection surgery were studied. All the patients had good outcomes, and three of them with intellectual disability showed improved intelligence after surgery. The power spectra characteristics of electrocorticography and the dynamic functional network changes of epileptic spasms were investigated. Electrocorticography power in the resected zone peaked 0.5 seconds before the clinica...
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