Up ‐regulation of transient receptor potential vanilloid (TRPV) and down‐regulation of brain‐derived neurotrophic factor (BDNF) expression in patients with functional dyspepsia (FD)

Conclusions & InferencesDespite lacking gastric mucosal inflammation, up‐regulation of TRPV1 and TRPV2, down‐regulation of BDNF were observed in FD patients. These suggest that immune alteration may contribute to the pathogenesis of FD without any previous infection. The study shows that there is up‐regulation of TRPV in visceral sensation, down‐regulation of BDNF and altered peripheral inflammatory Cytokines expression in patients with Functional Dyspepsia. The current findings suggest that new pathophysiology may be involved in dyspeptic patients without previous infection which is independent from mast cell or eosinophil activation.
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research