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Scientists find new way to attack antibiotic-resistant lung infections

Canadian scientists have discovered a possible way to break through the defences of some antibiotic-resistant respiratory infections.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news

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Conclusion High rates of favorable angiographic and clinical outcomes were found among AIS patients receiving ET in our single-center experience, particularly among transferred in patients. The establishment of a stroke network may help in the efficient transfer and assembly of appropriate resources for eligible patients that are transferred in for ET. PMID: 29683786 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Potentially deadly bacteria thriving in huge clots of waste in sewers, Channel 4 study showsFatbergs, the congealed mass of fat and discarded items that are increasingly blocking Britain ’s sewers, are the consequence of the plastic crisis in Britain and contain potentially deadly antibiotic-resistant bacteria, tests show.A study by Channel 4 in conjunction with Thames Water has analysed the contents of one supersize fatberg discovered underneath the streets of South Bank in central London.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: London Utilities Environment UK news Channel 4 Antibiotics Media Society Television industry Science Pollution Source Type: news
(Uppsala University) Antibiotic-resistant bacteria are a global and growing problem in health care. To be able to prevent further development of resistance developing, it is important to understand where and how antibiotic resistance in bacteria arises. New research from Uppsala University shows that low concentrations of antibiotics, too, can cause high antibiotic resistance to develop in bacteria.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
The naturally antibiotic-resistant bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a disease with stubbornly high mortality and a complex, protracted treatment regimen. The worldwide incidence of melioidosis is likely grossly underreported, though it is known to be highly endemic in northern Australia and Southeast Asia. Bacterial disulfide bond (DSB) proteins catalyze the oxidative folding and isomerization of disulfide bonds in substrate proteins. In the present study, we demonstrate that B. pseudomallei membrane protein disulfide bond protein B (BpsDsbB) forms a functional redox relay with the...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
In this study, we report the anti-QS activities of four different Chinese herbal plant extracts: Poria cum Radix pini, Angelica dahurica, Rhizoma cibotii and Schizonepeta tenuifolia, on Pseudomonas aeruginosa PAO1. All the plants extracted using hexane, chloroform and methanol were tested and found to impair swarming motility and pyocyanin production in P. aeruginosa PAO1, particularly by Poria cum Radix pini. In addition, all the plant extracts also inhibited violacein production in C. violaceum CV026 up to 50% while bioluminescence activities were reduced in lux-based E. coli biosensors, pSB401 and pSB1075, up to about 5...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Several types of dangerous bacteria ​,​ carrying genes that our antibiotics cannot fight​,​ are travelling the world hidden in ships' ballast tanks
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
(The University of Hong Kong) A novel solution to antimicrobial resistance -- HKU medical chemists discover peptic ulcer treatment metallodrug effective in 'taming' superbugs.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Recently, the prevalence of staphylococcal cassette chromosome mec (SCCmec) type IV isolates, which are the major community-acquired methicillin-resistant Staphylococcus aureus (MRSA), have increased in Japanese hospitals. The aim of this study was to elucidate the detailed molecular epidemiological features of the SCCmec type IV clones in Japanese hospitals. When 2589 MRSA isolated from four hospitals in Tokyo, Japan between 2010 and 2014 were analysed, the proportion of SCCmec type IV overtook that of type II, which was the major type of hospital-acquired MRSA in 2014. Multilocus sequence typing showed ...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
The 2013 Lancet Infectious Diseases Commission on antimicrobial resistance (AMR)1 called for coordinated international action. Subsequently, the WHO global action plan on AMR was adopted by the 68th World Health Assembly in May, 2015,2 as a sustainable development goal to spur worldwide action to tackle a very serious issue threatening global health security. Because accurate data on AMR worldwide were scarce at that time, it was anticipated that any data collection, surveillance, and research work on AMR would be scientifically rigorous and deliver quality data.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Comment Source Type: research
Pleun Joppe van Duijn and colleagues1 investigated the relative merits of antibiotic mixing and antibiotic cycling using a cluster-randomised crossover study in eight intensive care units (ICUs); their findings suggested that 9-month periods of cycling and mixing did not change the unit-wide prevalence of antibiotic-resistant, Gram-negative bacteria. We commend the design of this study, both for its scale and grounding in evolutionary theory that was drawn from the work of both experimentalists and mathematical modellers.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research
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