A mathematical crystal ball gazes into future of prostate cancer treatment
(University of Colorado Anschutz Medical Campus) Using open data from four previously conducted clinical trials, teams of international researchers designed mathematical models predicting the likelihood that a patient will discontinue docetaxel treatment due to adverse events.
Abstract Novel therapies to override chemo-radiation resistance in prostate cancer (PCa) are needed. Prostate cancer sphere-forming cells (PCSCs) (also termed prostate cancer stem-like cells) likely participate in tumor progression and recurrence, and they are important therapeutic targets. We established PCSC-enriched spheres by culturing human (DU145) and murine (TRAMP-C2) PCa cells in growth factor-defined serum-free medium, and we characterized stem-like properties of clonogenicity and tumorigenicity. The efficacy of two different oncolytic herpes simplex viruses (oHSVs) (G47Δ and MG18L) in PCSCs was tes...
Condition: Prostate Cancer Intervention: Procedure: Focal HIFU using PET-MRI/68Ga-PSMA imaging guidance Sponsor: Hospices Civils de Lyon Not yet recruiting
Conditions: Metastasis; Castration-resistant Prostate Cancer; Death Intervention: Diagnostic Test: Free PSA ratio test in patients after definitive treatment for localized prostate cancer Sponsors: Rabin Medical Center; University of Toronto Completed
This case report was exempt from approval by the authors ’ institutional review board. A 65-year-old male with no significant past medical history presented with a 6-month history of cloudy urine and white clumps that were more evident in the morning. Infectious disease work-up, which included filariasis work-up, was negative. Evaluation by a urologist found that the patient had nonmetastatic prostate cancer. Urine was sent for a chyluria screen (triglycerides and chylomicrons), which was positive.
Publication date: Available online 23 April 2019Source: Journal of Molecular BiologyAuthor(s): Michael Sebastian Ostertag, Wiebke Hutwelker, Oliver Plettenburg, Michael Sattler, Grzegorz Maria PopowiczAbstractBET proteins such as BRD3 are oncogenic transcriptional coactivators. SPOP binding triggers their proteasomal degradation. In both endometrial and prostate cancer, SPOP mutations occur in the MATH domain, but with opposed influence on drug susceptibility. In prostate cancer, SPOP mutations presumably cause increased BET levels, decreasing BET inhibitor drug susceptibility. As opposed, in endometrial cancer, decreased ...
Publication date: Available online 24 April 2019Source: Journal of Organometallic ChemistryAuthor(s): Serap Şahin-Bölükbaşı, Neslihan ŞahinAbstractThe aim of this study was to present the synthesis, characterization and anticancer activities of two novel benzimidazole-based NHC salts (1a-b) and their silver(I) complexes (2a-b) with methylbenzyl and isopropylbenzyl chains. All compounds were prepared using Schlenk techniques in an inert atmosphere. The carbene complexes were prepared with the interaction of carbene precursors and Ag2O. All new compounds were characterized by elemental analysis, LC-MS, FT-IR, 1...
CONCLUSION: Our data support a shortening of RTWI by RALP. PMID: 31012834 [PubMed - in process]
Authors: Arai Y, Ogawa O PMID: 31012829 [PubMed - in process]
ConclusionsT1-time correction has a significant influence on the intra- and inter-reader variability. By applying individually measured T1-time correction, both intra- and inter-observer variability were found to increase. Out of all investigated DCE parameters, kep is the most robust to this investigated bias.
ConclusionsThis work proposes a new NIRF probe ideal to target GRPR, biomarker of PCa. The promising data obtained suggest that the dye could allow the real-time intraoperative visualization of prostate cancer.