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UIowa study examines altered gene expression in heart failure

(University of Iowa Health Care) Heart tissue from patients with heart failure exhibits increased levels of Cdk8 protein. Mimicking this increased Cdk8 expression in transgenic mouse hearts alters gene expression in a way that promotes heart failure. When University of Iowa researchers examined the mouse heart cells before a decrease in heart function was detectable, they found over 3,400 genes already expressed with a profile similar to that of human heart muscle cells with dilated cardiomyopathy and heart failure.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obesity syndrome in humans, is associated with a reduction in autonomic tone, bradycardia, and incidence of obesity-associated hypertension. Thus, it has been assumed that melanocortin obesity syndrome may be protective with respect to obesity-associated cardiovascular disease. We show here that absence of the melanocortin-4 receptor (MC4R) in mice causes dilated cardiomyopathy, characterized by reduced contractility and increased left ventricular diameter. This cardiomyopathy is independent of obesity as weight matched diet induced obese mice d...
Source: eLife - Category: Biomedical Science Tags: Human Biology and Medicine Source Type: research
To verify that high thoracic epidural anesthesia (TEA) could reverse myocardial fibrosis in heart failure caused by dilated cardiomyopathy (DCM).
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
Conclusion Addition of Ivabradine to standard therapy in patients with DCM and symptomatic HF and targeting a heart rate <70/min improves symptoms, quality of life and various echocardiographic parameters.
Source: Indian Heart Journal - Category: Cardiology Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusions— Clinical, morphological, functional, haplotype, and segregation data all indicate that LMNA p.(Arg331Gln) is a pathogenic founder mutation with a phenotype reminiscent of other LMNA mutations but with a more benign course.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Etiology, Genetics, Cardiomyopathy, Mortality/Survival Original Articles Source Type: research
We report a case demonstrating a rapid and potent antiarrhythmic effect of biventricular pacing. A 67-year-old male patient with dilated cardiomyopathy was admitted for heart failure. The initial surface electrocardiogram revealed a left bundle branch block with a QRS complex duration of 200 ms. Echocardiographic examination revealed a left ventricular ejection fraction of 16%, a left ventricular end-diastolic dimension of 91 mm, and marked interventricular dyssynchrony. Continuous rhythm monitoring revealed frequently-recurring non-sustained monomorphic ventricular tachycardia (VT). Polymorphic VT, which persisted for 27 ...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Background In the conventional paradigm of the progression of left ventricular hypertrophy, a thick-walled left ventricle (LV) ultimately transitions to a dilated cardiomyopathy. There are scant data in humans demonstrating whether this transition occurs commonly without an interval myocardial infarction. Methods and Results Participants (n=1282) from the Dallas Heart Study underwent serial cardiac magnetic resonance 7 years apart. Those with interval cardiovascular events and a dilated LV (increased LV end-diastolic volume [EDV] indexed to body surface area) at baseline were excluded. Multivariable linear regression mode...
Source: Circulation: Heart Failure - Category: Cardiology Authors: Tags: Heart Failure, Hypertrophy, Remodeling, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research
This report is the first to describe the KCNJ12 gene as a cause of DCM in patients.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Background: Circulating levels of some amino acids are significantly decreased in heart failure patients. However, relationship between their levels and cardiac function remains unclear. We therefore examined association between amino acid levels and cardiac function as prognostic predictor in DCM patients. Methods: Consecutive 60 patients with DCM (M/F: 47/13, mean age: 59 years) were enrolled. We measured 25 kinds of plasma AA concentration, derivative of reactive oxygen metabolites (d-ROMs) as marker of oxidative stress, and washout rate of Tc-99m Sestamibi (WOR) as function of mitochondria and LVEF as LV function parameters.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
Background: Chronic intravenous inotropy is used as palliation therapy in patients with advanced heart failure (HF) who are not candidates for a left ventricular assist device or heart transplantation. However, the ultimate outcome of such patients is underreported. The purpose of this study was to describe the outcome of patients with advanced HF discharged on home inotropy. Methods: We carefully followed 14 patients that were discharged on palliative inotropes from June 2014 to November 2016. Median age was 69 years, 57% were males and 64% had non-ischemic dilated cardiomyopathy.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
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