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UIowa study examines altered gene expression in heart failure

(University of Iowa Health Care) Heart tissue from patients with heart failure exhibits increased levels of Cdk8 protein. Mimicking this increased Cdk8 expression in transgenic mouse hearts alters gene expression in a way that promotes heart failure. When University of Iowa researchers examined the mouse heart cells before a decrease in heart function was detectable, they found over 3,400 genes already expressed with a profile similar to that of human heart muscle cells with dilated cardiomyopathy and heart failure.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusion The elevation of the S100B protein after catheter ablation for ventricular arrhythmias is relatively common in our set. We did not identify any macroscopic changes on CT of CNS even by neurological examination. The level of renal insufficiency, the progression of cardiac failure, and the use of inhaled anesthesia with sevoflurane correlate with the amount of S100B as the biomarker of asymptomatic disability of CNS by patients receiving radiofrequency catheter ablation for ventricular arrhythmias.
Source: Cor et Vasa - Category: Cardiology Source Type: research
We present our initial experience using the HVAD as a bridge to heart transplantation in the pediatric population. We performed a retrospective, single center, nonrandomized review of 17 pediatric patients who underwent HVAD implantation between June 2013 and March 2016. The primary endpoints evaluated in this study were overall survival to heart transplantation, ongoing device support, or death. In this patient cohort, nine (53%) of 17 patients were male. The median age of the patients was 13.4 ± 3.8 (range 5–17) years. The median body surface area was 1.4 ± 0.4(0.7–2)...
Source: Artificial Organs - Category: Transplant Surgery Authors: Tags: Main Text Source Type: research
Authors: Gatzoulis KA, Arsenos P, Dilaveris P, Antoniou CK, Sideris S, Tousoulis D PMID: 28951196 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
Authors: Wang J, Li G, Yu D, Wong YP, Yong TF, Liang MC, Liao P, Foo R, Hoppe UC, Soong TW Abstract Recently, we reported that homozygous deletion of alternative exon 33 of CaV1.2 calcium channel in the mouse resulted in ventricular arrhythmias arising from increased CaV1.2Δ33 ICaL current density in the cardiomyocytes. We wondered whether heterozygous deletion of exon 33 might produce cardiac phenotype in a dose-dependent manner, and whether the expression levels of RNA splicing factors known to regulate alternative splicing of exon 33 might change in human heart failure. Unexpectedly, we found that exon 33(...
Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research
by Leslie Kennedy, Erin Kaltenbrun, Todd M. Greco, Brenda Temple, Laura E. Herring, Ileana M. Cristea, Frank L. Conlon By the age of 40, one in five adults without symptoms of cardiovascular disease are at risk for developing congestive heart failure. Within this population, dilated cardiomyopathy (DCM) remains one of the leading causes of disease and death, with nearly half of cases genetically determined. Though genetic and high throughput sequencing-based approaches have identified sporadic and inherited mutations in a multitude of genes implicated in cardiomyopathy, how combinations of asymptomatic mutations lead to c...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Conclusions Heart rate turbulence can be measured from the majority of good quality standard canine 24-hour Holter recordings with >5 VPCs. Turbulence onset is significantly reduced in Dobermans with preclinical DCM which indicates vagal withdrawal early in the course of disease. Heart rate turbulence is a powerful prognostic indicator in human cardiac disease which can be measured from standard 24-hour ambulatory ECG (Holter) recordings using appropriate computer software. Further studies are warranted to assess whether HRT may be of prognostic value in dogs with preclinical DCM and in other canine cardiac disease.
Source: Journal of Veterinary Cardiology - Category: Veterinary Research Source Type: research
Conclusions: Cardiopulmonary exercise testing is feasible in children with DCM and is useful to predict outcomes. The finding of lower exercise capacity and lower blood pressure response should prompt closer follow-up. In those with serial testing, a decline in exercise capacity may be a marker of clinical deterioration.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science-General Source Type: research
A 61-year-old man was admitted to our hospital for further treatment of worsening congestive heart failure with a mechanical ventilation. He had undergone a heart transplant due to dilated cardiomyopathy complicated with congenital myopathy at the age of 43. He had been suffering from cardiac allograft vasculopathy and had a history of right ventricular infarction complicated with acute inferior myocardial infarction when he was 59. Since then, refractory right-sided heart failure occurred and additional diuretics were required.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
Introduction: Refractory right ventricular failure (RVF) after the implantation of left ventricular assisted device (LVAD) is induced with increased morbidity and mortality. Case: A 23- year-old man with severe heart failure was hospitalized due to dilated cardiomyopathy with severe heart failure. Despite intensive care including intra-aortic balloon pumping and intravenous dobutamine, his cardiac function declined progressively and we decided to implant a LVAD as a bridge to transplantation. Three months after implantation, RVF was suspected due to the presence of leg edema and pleural effusion.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
Background: The numbers of heart transplant recipients are growing in japan. It is important to manage advanced heart failure patients not only in transplant institutions but also in non-transplant institutions. We evaluated clinical outcomes of heart transplant recipients in our institution. Method: We retrospectively reviewed 25 potential heart transplant candidates in our institution from 2005 to 2017. Result: Underlying disease of the patients were dilated cardiomyopathy (n  = 10, 56%), fulminant myocarditis (n = 4, 22%), and the others (ischemic cardiomyopathy, secondary cardiomyopathy and ...
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
More News: Cardiology | Cardiomyopathy | Dilated Cardiomyopathy | Genetics | Health Management | Heart | Heart Failure | Study