UIowa study examines altered gene expression in heart failure

(University of Iowa Health Care) Heart tissue from patients with heart failure exhibits increased levels of Cdk8 protein. Mimicking this increased Cdk8 expression in transgenic mouse hearts alters gene expression in a way that promotes heart failure. When University of Iowa researchers examined the mouse heart cells before a decrease in heart function was detectable, they found over 3,400 genes already expressed with a profile similar to that of human heart muscle cells with dilated cardiomyopathy and heart failure.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Dogs that eat grain-free diets may be more prone to develop a canine cardiovascular disease that has historically been seen in just a few breeds. The U.S. Food and Drug Administration's Center for Veterinary Medicine and a group of veterinary diagnostic laboratories are investigating the potential link between canine dilated cardiomyopathy (DCM) and pet foods containing seeds or potatoes as main ingredients.  Breeds genetically predispose d to DCM, which often results in congestive heart failure,…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
Conclusions: Our data support DCM as a genetically heterogeneous disease with, at times, multigene causation. Although the frequency of DCM resulting from multigenic cause is uncertain, our data suggest it may be higher than previously anticipated.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Genetics, Cardiomyopathy, Heart Failure Original Articles Source Type: research
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Genetics, Cardiomyopathy, Heart Failure Editorial Source Type: research
Improved control of communicable diseases and longer life expectancy in developing countries has led to an increased prevalence of chronic diseases.1 Cardiovascular disease is the leading cause of death world-wide, with over three-quarters of those deaths occurring in low or middle-income countries.2 Heart failure (HF), in particular, is a major cause of mortality in South American countries. This is driven by an increasing prevalence of ischemic cardiomyopathy, dilated cardiomyopathy, and hypertensive heart disease.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Clinical Investigation Source Type: research
Treatment decisions in dilated cardiomyopathy (DCM) patients with severe heart failure (HF) and short clinical history are challenging because of the difficulty of determining HF stage or prognosis in the acute HF phase. We hypothesized that persistent decreased systemic or increased pulmonary arterial pressure, including in the subclinical phase, may affect the main pulmonary artery diameter (PAD), ascending aortic diameter (AoD), and their ratio (PAD/AoD). The aims of this study were to assess AoD, PAD, and PAD/AoD by non-contrast computed tomography (CT) scans in DCM patients in the acute phase of HF and to examine the ...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Potato-based pet foods may be causing heart disease in dogs, the U.S. Food &Drug Administration warned this week. The government agency is investigating a potential link between pet foods with peas, lentils, potatoes and other legume seeds and instances of canine dilated cardiomyopathy in dogs not typically vulnerable to the disease. “Highly unusual” reports of these dogs contracting the disease prompted the FDA to investigate their food sources, which, the agency notes, largely contained those certain ingredients. .@FDAanimalhealth is investigating the potential association between reports of canine dil...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime Pets Source Type: news
ConclusionsInvasively-determined fibrosis levels were not related with CV outcomes in DCM. Out of the 11 markers of fibrosis under study, only OPN was found to be related to CV outcomes. OPN is not only the pivotal protein controlling fibrosis, but may also serve as a biomarker associated with prognosis.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Publication date: Available online 22 April 2018Source: PeptidesAuthor(s): Takayuki Shindo, Megumu Tanaka, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Akihiro Yamauchi, Takayuki SakuraiAbstractAdrenomedullin (AM), a member of the calcitonin peptide superfamily, is a peptide involved in both the pathogenesis of cardiovascular diseases and circulatory homeostasis. Its receptor, calcitonin receptor-like receptor (CLR), associates with an accessory protein, receptor activity-modifying protein (RAMP). Depending upon which the three RAMP isoforms (RAMP1-3) it interacts with, CLR functions as a receptor for AM or other ...
Source: Peptides - Category: Biochemistry Source Type: research
P Rastogi, A Dua, S Attri, H SharmaJournal of Postgraduate Medicine 2018 64(3):177-179 Dilated cardiomyopathy (DCM) is an idiopathic condition that results from impaired ventricular systolic function. Thyroid diseases have been known to cause myriad changes in the structure and function of the heart. Diastolic dysfunction is a common abnormality reported in hypothyroidism. However, hypothyroidism-induced DCM and systolic dysfunction is an uncommon phenomenon, especially as the initial presenting manifestation of hypothyroidism. The current article describes the case of a young female who presented with symptoms of heart f...
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
In conclusion, HIMF has a critical role in the development of cardiac hypertrophy, and targeting HIMF may represent a potential therapeutic strategy.
Source: Hypertension - Category: Cardiology Authors: Tags: Heart Failure, Hypertrophy Original Articles Source Type: research
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