How a tick gut gene serves as a gateway for Lyme disease
The bacterium that causes Lyme disease may have some help from a gene found in the guts of infected ticks.
This article is protected by copyright. All rights reserved. Borrelia burgdorferi, Lyme disease agent, harbors no enzymes to synthesize or degrade polyamines yet does contain the genes encoding a putative polyamine uptake system (potABCD). Here, we demonstrated that the PotABCD is a spermidine‐specific transporter system that is essential for survival. The genes are upregulated during tick feeding concomitantly with the decrease of osmoliarity which has been shown to trigger virulence factor expression. The potABCD genes are regulated in a RpoN‐dependent, RpoS‐independent, BosR‐independent fashion.
Publication date: 3 April 2018 Source:Neuroscience Letters, Volume 671 Author(s): Geetha Parthasarathy, Mario T. Philipp Lyme neuroborreliosis, caused by the gram-negative bacterium Borrelia burgdorferi, may affect the central and/or peripheral nervous systems. In previous studies, we showed that human oligodendrocytes exposed to the bacteria undergo apoptosis in an inflammatory environment, and that inflammatory pathways trigger cell-death pathways. We further demonstrated that several receptor tyrosine kinases were involved in triggering downstream effects, leading to inflammation and apoptosis. Toll-like receptors TLR2...
Cerebrospinal fluid CXCL13 is a marker for Lyme neuroborreliosis (LNB). CXCL13 lateral flow immunoassay (LFA) was compared to CXCL13 ELISA. CXCL13 LFA results correlated strongly with CXCL13 ELISA results. CXCL13 LFA is a rapid and easy to perform test, which is suitable for routine point-of-care diagnostics of suspected LNB patients.
Borrelia burgdorferi infection is common in horses living in Lyme endemic areas and the geographic range for exposure is increasing. Morbidity after B. burgdorferi infection in horses is unknown. Documented, naturally occurring syndromes attributed to B. burgdorferi infection in horses include neuroborreliosis, uveitis, and cutaneous pseudolymphoma. Although other clinical signs such as lameness and stiffness are reported in horses, these are often not well documented. Diagnosis of Lyme disease is based on exposure to B. burgdorferi, cytology or histopathology of infected fluid or tissue and antigen detection. Treatment of...
Conclusion: NFS is a unique tool that can be used universally to assess the condition of patients with LD.
Conclusions and Clinical ImportancePositive Lyme multiplex results were common in horses with neurologic diseases and did not adequately differentiate horses with neuroborreliosis from horses with other disorders.
Authors: Boyer PH, Kieffer P, de Martino SJ, Zilliox L, Vogel JY, Jaulhac B, Hansmann Y PMID: 29449048 [PubMed - as supplied by publisher]
It was an exercise session in a local park that almost became the mother-of-two Nell McAndrew's undoing – after a tiny tick bite led to her developing potentially life-changing Lyme disease.
(Natural News) A study, published in the journal Frontiers in Medicine, found that more than 50 percent of Lyme disease survivors still suffer from severe, persistent symptoms even after being clinically cleared of the infection. A team of researchers from John Hopkins University School of Medicine evaluated 61 individuals who were either self- or physician-referred...
In this study using 3956 control sera, we demonstrated that although this 2-tier testing algorithm does significantly improve diagnostic specificity compared with each of the EIAs individually, the WCS EIA and the C6 peptide EIA are not independent tests.