Researchers develop stem cell therapy to fight inflammatory lung conditions

Credit: NC State / UNC Researchers from the UNC School of Medicine and North Carolina State University showed that they could harvest and multiply lung stem cells in volumes sufficient for human therapy.  In a second study, the team used their cell therapy to treat a model of idiopathic pulmonary fibrosis. The scientists reported that they are in talks with the FDA to prepare for an initial clinical trial with IPF pat Get the full story at our sister site, Drug Delivery Business News. The post Researchers develop stem cell therapy to fight inflammatory lung conditions appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Research & Development Respiratory Stem Cells Source Type: news

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In this study, we tried to demonstrate the effects of adding human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) to carvedilol in improving the doxorubicin- induced cardiotoxicity in rats. Rats were randomly divided into four groups: group 1: control group, group 2: doxorubicin untreated group, group 3: rats injected with doxorubicin and received carvedilol, and group 4: rats injected with doxorubicin and received carvedilol and stem cell-treated. Electrocardiography (ECG) was performed to assess cardiac function after animals were sacrificed. Cardiac muscle sections were examined histologically using H&E, Masson...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
CONCLUSION: hucMSC-Ex, in a dose-dependent manner, can improve the morphology of placental tissue in rats with PE, by inhibiting cell apoptosis and promoting angiogenesis in placental tissue. PMID: 30021360 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Publication date: 1 November 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 171Author(s): Junyan Yan, Shulan Hou, Yanzhen Yu, Yong Qiao, Tongqian Xiao, Yan Mei, Zhijun Zhang, Bin Wang, Chih-Ching Huang, Chia-Hua Lin, Guangli SuoAbstractCarbon quantum dots (CQDs) are emerging as an ideal agent for efficient stem cell labeling. In current study, we synthesized a series of CQDs carrying different surface charges by changing the mass ratio of diammonium citrate (DC) and spermidine (Spd), and evaluated the effects of different surface charges on the cytotoxicity, cellular uptake, stability in human umbilical cord de...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
This study focused on examining how students’ perception and understanding of the tissue engineering field changed as a result of their participation in a hands-on experiential learning module. The module involved the cellular and biochemical characterization of three-dimensional cultures of mesenchymal stem cells in chondrogenic media. Students were instructed to complete concept maps depicting their perception of the tissue engineering field both prior to and after completion of the module. Similarly, they had to respond to provided design prompts and identify experimental tests and questions for doctors that would...
Source: Education for Chemical Engineers - Category: Chemistry Source Type: research
In conclusion, silvestrol could be identified as pangenotypic HEV replication inhibitor in vitro with additive effect to RBV and further demonstrated high potency in vivo. The compound therefore may be considered in future treatment strategies of chronic hepatitis E in immunocompromised patients.
Source: Antiviral Therapy - Category: Virology Source Type: research
Contributors : Manlio Vinciguerra ; Tommaso MazzaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe recently described the phenotytpe of HepG2 and Huh-7 hepatocellular carcinoma cells deleted for histone variant macroH2A1, which acquire cancer stem cell phenotype (Lo Re O et al., Hepatology 2017, PMID: 28913935). We found that short hairpin RNA-mediated macroH2A1 knockdown induces acquisition of CSC-like features, including the growth of significantly larger and less differentiated tumors when injected into nude mice. MacroH2A1-depleted HCC cells also exhibited reduced proliferation, ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
We report that cigarette smoking augments pancreatic CSCs and this process occurs by the activation of Paf1/PD2, a major stem ness marker. We also report that the cigarette smoke activates Paf1/PD2 through nACHR α7-ERK1/2-FOSL1 signaling axis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Kanella Prodromidou ; Ioannis S Vlachos ; Maria Gaitanou ; Georgia Kouroupi ; Artemis Hatzigeorgiou ; Rebecca MatsasSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensTo identify microRNAs (miRNAs) with a key role in the molecular mechanisms controlling human neurogenesis, we performed deep sequencing of small and long RNA transcripts at distinct stages of directed neuronal differentiation of human embryonic and induced pluripotent stem cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: September 2018Source: Molecular Genetics and Metabolism Reports, Volume 16Author(s): Kishore R. Kumar, Gautam Wali, Ryan L. Davis, Amali C. Mallawaarachchi, Elizabeth E. Palmer, Velimir Gayevskiy, Andre E. Minoche, David Veivers, Marcel E. Dinger, Alan Mackay-Sim, Mark J. Cowley, Carolyn M. SueAbstractZellweger syndrome spectrum disorders are caused by mutations in any of at least 12 different PEX genes. This includes PEX16, an important regulator of peroxisome biogenesis. Using whole genome sequencing, we detected previously unreported, biallelic variants in PEX16 [NM_004813.2:c.658G>A, p.(Ala220Thr) ...
Source: Molecular Genetics and Metabolism Reports - Category: Genetics & Stem Cells Source Type: research
Authors: Shallis RM, Chokr N, Stahl M, Pine AB, Zeidan AM Abstract INTRODUCTION: Myelodysplastic syndromes (MDS) encompass a heterogenous collection of clonal hematopoietic stem cell disorders defined by dysregulated hematopoiesis, peripheral cytopenias, and a risk of leukemic progression. Increasing data support the role of innate and adaptive immune pathways in the pathogenesis and disease course of MDS. The role of immunosuppressive therapy has an established role in the treatment of other hematologic diseases such as aplastic anemia whose pathogenesis is postulated to reflect that of MDS with regards to many as...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
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