Researchers develop stem cell therapy to fight inflammatory lung conditions
Credit: NC State / UNC Researchers from the UNC School of Medicine and North Carolina State University showed that they could harvest and multiply lung stem cells in volumes sufficient for human therapy. In a second study, the team used their cell therapy to treat a model of idiopathic pulmonary fibrosis. The scientists reported that they are in talks with the FDA to prepare for an initial clinical trial with IPF pat Get the full story at our sister site, Drug Delivery Business News. The post Researchers develop stem cell therapy to fight inflammatory lung conditions appeared first on MassDevice.
Authors: Ho NTT, Kutzner A, Heese K Abstract Due to an aging society with an increased dementia-induced threat to higher cognitive functions, it has become imperative to understand the molecular and cellular events controlling the memory and learning processes in the brain. Here, we suggest that the novel master gene pair |-SRGAP2-FAM72-| (SLIT-ROBO Rho GTPase activating protein 2 - family with sequence similarity to 72) reveals a new dogma for the regulation of neural stem cell (NSC) gene expression and is a distinctive player in the control of human brain plasticity. Insight into the specific regulation of the br...
Nature Reviews Neuroscience 18, 511 (2017). doi:10.1038/nrn.2017.109 Author: Darran Yates Hypothalamic neural stem cells may be important regulators of the speed at which ageing proceeds in mice.
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CONCLUSIONS: Knowledge regarding factors associated with increased LOS and 30-day readmission can help nurses and transplantation team members anticipate the healthcare needs of patients receiving HSCT, improve outcomes, and decrease the use of expensive health services. . IMPLICATIONS FOR NURSING: Educating patients and caregivers on infection prevention is critically important to reduce LOS and 30-day readmission after HSCT. PMID: 28820507 [PubMed - in process]
This study didn't measure whether receiving the cardiosphere-derived cells extended lifespans, so we have a lot more work to do. We have much to study, including whether CDCs need to come from a young donor to have the same rejuvenating effects and whether the extracellular vesicles are able to reproduce all the rejuvenating effects we detect with CDCs." Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats Cardiosphere-derived cell (CDC) therapy has exhibited several favourable effects on heart structure and function in humans and in preclinical models; however,...
We report a case of cutaneous ICH occurring after allogeneic hematopoietic stem-cell transplantation for a myelodysplastic syndrome in a 56-year-old man. Microsatellite analysis demonstrated that the neoplastic cells were derived from the donor's hematopoietic system. This case broadens the spectrum of complications after stem-cell transplantation and demonstrates that cutaneous ICH in the setting of myelodysplastic syndromes may have a nonrelated origin to dysplastic myeloid cells.
Conclusions These results indicate that THs favor NSC fate choice toward a neuronal phenotype in the adult mouse SVZ through effects on mitochondrial metabolism. Graphical abstract
This article is protected by copyright. All rights reserved. Insulin stimulates proliferation of adult neural stem cells (NSC) to form neurospheres through activation of insulin receptor substrate IRS2 and protein kinase B (PKB/AKT) leading to increased activity of cyclin‐dependent kinase CDK4. Activation of the same pathway mediates the effects of insulin in promoting the differentiation of neurons (in red) and oligodendrocytes (in green) and in neuritogenesis.
Publication date: Available online 20 August 2017 Source:Pharmacology & Therapeutics Author(s): Mohini Singh, Nicolas Yelle, Chitra Venugopal, Sheila K. Singh Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in normal mammalian development for decades, and it has been proposed as a critical mechanism during cancer progression and metastasis. EMT is tightly regulated by several internal and external cues that orchestrate the shifting from an epithelial-like phenotype into a mesenchymal ph...
Publication date: Available online 19 August 2017 Source:Pharmacology & Therapeutics Author(s): Jinhua Wang, Wan Li, Ying Zhao, De Kang, Weiqi Fu, Xiangjin Zheng, Xiaocong pang, Guanhua Du FOX families play important roles in biological processes, including metabolism, development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here we are focusing on roles of FOX members in cancers, FOX members and drug resistance,FOX members and stem cells. Finally, FOX members as drug targets of cancer treatment were discussed. Future perspectives of FOXC1 research were described in the end.