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Researchers develop stem cell therapy to fight inflammatory lung conditions

Credit: NC State / UNC Researchers from the UNC School of Medicine and North Carolina State University showed that they could harvest and multiply lung stem cells in volumes sufficient for human therapy.  In a second study, the team used their cell therapy to treat a model of idiopathic pulmonary fibrosis. The scientists reported that they are in talks with the FDA to prepare for an initial clinical trial with IPF pat Get the full story at our sister site, Drug Delivery Business News. The post Researchers develop stem cell therapy to fight inflammatory lung conditions appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Research & Development Respiratory Stem Cells Source Type: news

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Authors: Kadoya K, Makino ET, Jiang LI, Bachelor M, Chung R, Tan P, Cheng T, Naughton GK, Mehta RC Abstract Skin care products may use various active ingredients to support skin rejuvenation including growth factors and other molecules that help to regenerate extracellular matrix (ECM) and promote skin repair. The biological effect of skin care products with a strong anti-aging claim was assessed in gene expression analyses using an in vitro human skin model. Application of products containing human fbroblast-derived growth factors resulted in signifcant upregulation of genes encoding ECM components including colla...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Authors: Aimetti M, Ferrarotti F, Gamba MN, Giraudi M, Romano F Abstract The present case series aimed to explore the potential clinical benefits of the application of dental pulp stem cells (DPSCs) in the regenerative treatment of deep intrabony defects. A total of 11 isolated intrabony defects in 11 chronic periodontitis patients were accessed with a minimally invasive flap and filled with DPSCs loaded on a collagen sponge. A tooth requiring extraction for impaction or malpositioning was used as an autologous source for DPSCs. An average clinical attachment level gain of 4.7 ± 1.5 mm associated with a resi...
Source: International Journal of Periodontics and Restorative Dentistry - Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research
Authors: Wang Y, Feng L, Piao B, Zhang P Abstract Cancer stem cells (CSCs) are small subpopulations of neoplastic cells within a tumor, which have self-renewal and differentiation abilities and could generate new tumors with few cells. Researches have showed that CSCs are considered the most likely reason for cancer recurrence and metastasis. Accumulating evidences have showed that traditional Chinese medicine (TCM) has significant effect on CSCs. It could inhibit the proliferation, self-renew, and multidifferentiation of CSCs. We aimed to summarize the theories of CSCs in TCM, the inhibitory effect, and the pathwa...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: Article Source Type: research
Darvadstrocel is the first allogeneic stem cell therapy to receive a positive CHMP opinion in Europe.International Approvals
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Funding Opportunity PA-18-500 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to encourage applications that seek to conduct studies of the visual system. Eligible applications may be either: Those that involve human subjects, but are not NIH-defined clinical trials (see NOT-OD-15-015); or Those that are NIH-defined clinical trials and are designed to address either: 1) mechanisms underlying human vision in health and disease; or 2) interventions that entail procedures with minimal risk to subjects. More information about eligibility can be found in Part 2 Section III.3. A mechanistic trial is defi...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
In conclusion, age associated decrease in efficiency of stem cells can be responsible for the degenerative cardiac changes in physiological aging. Aging of CSCs can affect migration and proliferation and promote apoptosis. Accelerated aging in stem cells isolated from hearts of SHR is possibly mediated by an adverse microenvironment. Decrease in the healthy stem cell pool can affect efficient tissue repair and precipitate the transition from compensated hypertrophy to cardiac failure. Enhanced oxidative stress in the microenvironment can be a predominant factor contributing to stem cell aging. The salient findings of accel...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Authors: Abstract We are pleased to announce that the following 4 articles have been selected for the the UEDA Heart Awards for the Year 2017.First PlaceGeneration of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to CardiomyocytesAkihito Hashimoto, Atsuhiko T. Naito, Jong-Kook Lee, Rika Kitazume-Taneike, Masamichi Ito, Toshihiro Yamaguchi, Ryo Nakata, Tomokazu Sumida, Katsuki Okada, Akito Nakagawa, Tomoaki Higo, Yuki Kuramoto, Taku Sakai, Koji Tominaga, Takeshi Okinaga, Shigetoyo Kogaki, Keiichi Ozono, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata, Hiroyuki Mori...
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The population of stem cells that supports muscle tissue is one of the better studied classes of such cell. Stem cells enable tissue maintenance and regeneration by delivering a supply of new daughter somatic cells that can multiple to make up losses, and through signaling that alters cell behavior. This activity declines with advancing age, however, with stem cells spending ever more of their time in a quiescent state. This is thought to be a response to rising levels of cell damage and tissue dysfunction, behavior that evolved because it serves to reduce the risk of cancer over a period in which our ancestors were under ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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