Diabetes drug may be helpful for Parkinson's disease
Conclusion This research shows some interesting early findings, though the magnitude of effect was very small compared to the improvements in symptoms with current dopaminergic drugs. The study was well conducted but did have some limitations: The number of people taking part was quite small. This may have meant it was hard to detect any other benefits or harms of taking the drug other than the effects on motor scores. The period of time people were given the drug and followed up meant that longer-term effects could not be measured. The benefit of the drug observed so far might not be big enough to make a difference to people's day-to-day lives, but this may change with a longer or larger study. Overall, this well-designed piece of research indicates that it would be worth carrying out further studies of longer-term outcomes in bigger populations. It could well be the case that a repurposed version of exenatide, or similar GLP-1 agonist, could prove more successful. Links To The Headlines Diabetes drug could help those living with Parkinson's disease, research reveals. The Guardian, August 4 2017 First hints Parkinson's can be stopped. BBC News, August 4 2017 Type 2 diabetes drug could combat Parkinson's: Test results suggest treatment could stop the disease in its tracks. Mail Online, August 4 2017 Cheap diabetes drug exenatide helps Parkinson’s patients move. The Times, August 4 2017 (subscription required) Links To Science Athauda D, Maclagan K, Skene SS, e...
Publication date: Available online 4 April 2020Source: Journal of Geriatric OncologyAuthor(s): Claire A. Surr, Rachael Kelley, Alys W. Griffiths, Laura Ashley, Fiona Cowdell, Ann Henry, Michelle Collinson, Ellen Mason, Amanda J. Farrin
Conclusions: In the current study, the prevalence of depression among diabetic outpatients was higher than that of studies conducted in other settings. Depression was significantly associated with female sex, rural residency, type 2 diabetes mellitus, duration of illness> 6 years, high fear of complications, and poor social support. PMID: 32243106 [PubMed - as supplied by publisher]
CONCLUSIONS By downregulating expression of the SNHG5 gene and then altering expression of the TGR5 gene, the damage to colorectal cells induced by high glucose was alleviated. This may be one of the mechanisms underlying the effect of sleeve gastric surgery in treatment of diabetes mellitus. PMID: 32242546 [PubMed - in process]
This study was an open-label, parallel controlled study. Patients were included if they were newly diagnosed with type 2 diabetes (
CONCLUSIONS In this study, we screened 104 lncRNA therapeutic targets and several signaling pathways (Wnt, PPAR, amino acid metabolism signaling pathway, mTOR, and lipid metabolism-related pathways) of liraglutide against T2DM based on lncRNA sequencing. PMID: 32238798 [PubMed - in process]
CONCLUSIONS A prognostic model based on six variables was predictive for incident type 2 diabetes mellitus and prediabetes in a healthy population in Japan. PMID: 32235819 [PubMed - in process]
Authors: Oliveira R, Teodoro T, Botelho A PMID: 32238246 [PubMed - in process]
CONCLUSION: The current study showed that man gender, diabetes and hypertension were the greatest risk factors for PAD. We conclude that man patients with diabetes and/or hypertension should be put under serious consideration for routine CTA examination when under evaluation for LSS and intermittent claudication. PMID: 32242344 [PubMed - in process]
CONCLUSIONS: The positive effect of the interaction on the executive function has been observed, specifically in the capacities for planning and sequencing, perceptual organisation, response inhibition, logical reasoning and mental flexibility. PMID: 32242333 [PubMed - in process]
Abstract Few studies have examined the relationship between the use of antidepressants and the onset of hyperglycemia and diabetes mellitus in Japan. We herein explored the possibility of this relationship using the Japanese Adverse Drug Event Report database (JADER). The present study included 20 individual antidepressants, consisting of 6 subclasses, which have been approved for use in Japan. We used Standardized MedDRA Queries 20000041 to extract patients who developed hyperglycemia/new onset diabetes mellitus (NODM) in JADER between April 2004 and September 2016. We calculated reporting odds ratios (RORs) with...