Heart rate control is associated with the reduced cardiovascular events in Asian patients with coronary artery disease treated with bisoprolol (BISO-CAD): results from a multi-national, real-world experience.

Heart rate control is associated with the reduced cardiovascular events in Asian patients with coronary artery disease treated with bisoprolol (BISO-CAD): results from a multi-national, real-world experience. Curr Med Res Opin. 2017 Aug 02;:1-27 Authors: Chen Y, Yang X, Nguyen Pham V, Huang S, Fu G, Chen X, Quang Truong B, Yang Y, Liu S, Chen X, Ma T, Kim DS, Kim TH Abstract OBJECTIVE: To evaluate the association between decrease in resting heart rate (RHR) and occurrence of composite cardiac clinical outcomes in coronary artery disease (CAD) patients after bisoprolol treatment. METHODS: This phase IV, multi-national, single-arm, open-label, non-randomized, observational trial was conducted between October 2011 to April 2014 across 40 hospitals from China, South Korea and Vietnam. RESULTS: Analysis of 866 patients (mean age 63.85 ± 10.35; mean RHR at baseline 75.71 ± 6.87 bpm in intent-to-treat (ITT); 75.56 ± 6.73 in efficacy analysis (EA) sets) was done. Patients with lower mean RHR had less composite cardiac events and patients with RHR of 69-74bpm reported significantly higher outcomes than patients with RHR
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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