Voluntary wheel running augments aortic l-arginine transport and endothelial function in rats with chronic kidney disease.

VOLUNTARY WHEEL RUNNING AUGMENTS AORTIC L-ARGININE TRANSPORT AND ENDOTHELIAL FUNCTION IN RATS WITH CHRONIC KIDNEY DISEASE. Am J Physiol Renal Physiol. 2014 Jun 25; Authors: Martens CR, Kuczmarski JM, Kim J, Guers JJ, Harris MB, Lennon-Edwards S, Edwards DG Abstract Reduced nitric oxide (NO) synthesis contributes to risk for cardiovascular disease in chronic kidney disease (CKD). Vascular uptake of the NO precursor L-arginine (ARG) is attenuated in rodents with CKD, resulting in reduced substrate availability for NO synthesis and impaired vascular function. We tested the effect of 4 weeks of voluntary wheel running (RUN) and/or ARG supplementation on endothelium-dependent relaxation (EDR) in rats with CKD. 12 week old male Sprague Dawley rats underwent 5/6 ablation infarction surgery to induce CKD, or SHAM surgery as a control. Beginning 4 weeks following surgery, CKD animals either remained sedentary (SED) or received one of the following interventions: supplemental ARG, RUN, or combined ARG+RUN. Animals were sacrificed 8 weeks after surgery and EDR was assessed. EDR was significantly impaired in SED vs. SHAM animals after 8 weeks, in response to Acetylcholine (Ach; 10(-9)-10(-5) M) as indicated by a reduced area under the curve (AUC; 44.56 ± 9.01 vs 100 ± 4.58, p<0.05) and reduced maximal response (Emax; 59.9% ± 9.67 vs 94.31% ± 1.27, p <0.05). AUC was not improved by ARG treatment but was significantly improved above SED ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research