Chronic kidney disease: Targeting prostaglandin E2 receptors.

Chronic kidney disease: Targeting prostaglandin E2 receptors.
Am J Physiol Renal Physiol. 2014 Jun 25;
Authors: Nasrallah R, Hassouneh R, Hebert RL
Abstract
Chronic kidney disease is a leading cause of morbidity and mortality in the world. A better understanding of disease mechanisms has been gained in recent years, but the current management strategies are ineffective at preventing disease progression. A widespread focus of research is placed on elucidating the specific processes implicated to find more effective therapeutic options. Prostaglandin E2 acting on its four EP receptors regulates many renal disease processes, thus EP receptors could prove to be important targets for kidney disease intervention strategies. This review summarizes the major pathogenic mechanisms contributing to initiation and progression of chronic kidney disease, emphasizing the role of hyperglycemia, hypertension, inflammation and oxidative stress. We have long recognized the multifaceted role of prostaglandins in both the initiation and progression of chronic kidney disease, yet studies are only now seriously contemplating specific EP receptors as targets for therapy. Given the plethora of renal complications attributed to prostaglandin involvement in the kidney, this review highlights these pathogenic events and emphasizes the prostaglandin E2 receptor targets as options available to complement current therapeutic strategies.
PMID: 24966087 [Pub...

Source: Am J Physiol Renal P... - June 25, 2014 Category: Urology & Nephrology Authors: Nasrallah R, Hassouneh R, Hebert RL Tags: Am J Physiol Renal Physiol Source Type: research