Differential effect of T-type voltage-gated calcium channel disruption on renal plasma flow and glomerular filtration rate in vivo.

In conclusion, Cav 3.2 channels support dilatation of efferent arterioles and affect GFR while Cav 3.1 channels in vivo contribute to renal vascular resistance. It is suggested that endothelial and nerve localization of Cav 3.2 and Cav 3.1, respectively, may account for the observed effects.
PMID: 24966091 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - June 25, 2014 Category: Urology & Nephrology Authors: Thuesen AD, Andersen H, Cardel M, Toft A, Walter S, Marcussen N, Jensen BL, Bie P, Hansen PB Tags: Am J Physiol Renal Physiol Source Type: research