Change in Conversion Definition May Improve TB Detection
Increase from IFN γ0.7 IU/mL would improve identification of those at risk of tuberculosis
CONCLUSIONS: In this paper, we describe the importance and implementation of USFDA's tentative approval process to review ARVs for resource-constrained settings. We also highlight the impact of patents and exclusivities on review of HIV drugs under tFDA and illustrate the concepts using a new HIV drug as an example. PMID: 29232052 [PubMed - in process]
CONCLUSION: The tubercular hypophysitis, as a result of performed tests, is discussed hereby, in the case report. PMID: 29232189 [PubMed - in process]
We report a case of HIV-associated opsoclonus-myoclonus and early HIV infection. A review of published literature shows opsoclonus-myoclonus can occur during early infection, in immune reconstitution syndrome or in association with other infections, especially tuberculosis.
For the first time, a urine test has been developed that reliably detects tuberculosis – a valuable weapon in the fight against an infection that kills millions
European Union, European Centre for Disease Prevention and Control. 11/13/2017 This 228-page report presents the results of the zoonoses monitoring activities carried out in 2016 in 37 European countries (28 Member States [MS] and nine non-MS). It summarizes trends and sources for Yersinia (plague) and tularemia, both Category A bioterrorism agents; brucella, a Category B bioterrorism Agent; bovine tuberculosis, trichinellosis, echinococcosis, toxoplasmosis, rabies, Q fever, and West Nile fever. (PDF)
Abstract Protein-protein interaction (PPI) network analysis is a powerful strategy to understand M. tuberculosis (Mtb) system level physiology in the identification of hub proteins. In the present study, the PPI network of 79 Mtb toxin-antitoxin (TA) systems comprising of 167 nodes and 234 edges was investigated. The topological properties of PPI network were examined by 'Network analyzer' a cytoscape plugin app and STRING database. The key enriched biological processes and the molecular functions of Mtb TA systems were analyzed by STRING. Manual curation of the PPI data identified four proteins (i.e. Rv2762c, Vap...
Authors: Khan N, Vidyarthi A, Pahari S, Agrewala JN Abstract Dendritic cells (DCs) and macrophages (Mϕs) are professional antigen-presenting cells (APCs) that can efficiently phagocytose Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB). It is quite interesting to mention here that DCs and Mϕs use distinct strategies to combat and eliminate Mtb. Similarly, Mtb employs different mechanisms to counteract the action of DCs and Mϕs. Mϕs are evolved with specialized, innate, defensive machinery to restrict growth of Mtb at the initial phase of infection. However, DCs are more endowed towar...
(American Association for the Advancement of Science) Scientists have finally developed a noninvasive tuberculosis test for a pool of people for whom such assessments have previously been difficult: people who don't have HIV.
Authors: Kim CH, Kim EJ, Cha SI, Lee J PMID: 29225259 [PubMed - as supplied by publisher]