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Erratum to: Trends in Research Literature Describing Dysphagia in Motor Neuron Diseases (MND): A Scoping Review

Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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The news about mechanistic therapies in neurodegeneration has been generally rather glum, particularly with the disappointing results of trials targeting β-secretase for Alzheimer's disease. However, in my view, the most important development in neurodegeneration research in 2017 has been the introduction of successful gene-based therapies for spinal muscular atrophy, which is caused by mutations in the SMN1 gene.1,2 One phase 1–2 trial1 assessed the effect of injection of adeno-associated virus carrying SMN1 cDNA, and a phase 3 trial2 assessed intrathecal injection of an antisense oligonucleotide (nusinersen) t...
Source: Lancet Neurology - Category: Neurology Authors: Tags: 2017 Round-up Source Type: research
Success in trials for Huntington ’s and Spinal Muscular Atrophy raises hopes that diseases such as Alzheimer’s and ALS could be tackled using a new class of drugsThey are diseases that threaten more than physical health: memories, personality, and the ability to move and speak are incrementally stolen. And until this year neurodegenerative diseases, from Alzheimer ’s toALS, had been entirely unstoppable.However, abreakthrough in Huntington ’s disease this week suggests this bleak picture could be about to change. The landmark trial was the first to show that the genetic defect that causes Huntington...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Neuroscience Alzheimer's Motor neurone disease Parkinson's disease Genetics Drugs Health Biology Source Type: news
The objective of this study was to investigate how adverse effects of chronic exposure to non-toxic levels of essential and non-essential metals in early life stage zebrafish may be explained by changes in the transcriptome. We therefore studied the effects of three different metals at low concentrations in zebrafish embryos by transcriptomics analysis. The study design compared exposure effects caused by different metals at different developmental stages (pre-hatch and post-hatch). Wild-type embryos were exposed to solutions of low concentrations of copper (CuSO4), cadmium (CdCl2) and cobalt (CoSO4) until 96h post-fertili...
Source: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics - Category: Genetics & Stem Cells Source Type: research
This article is protected by copyright. All rights reserved. “Intricate and self‐perpetuating cellular interplay underlies amyotrophic lateral sclerosis (ALS). Disease stage is a key determinant of cell type‐specific molecular mechanisms”.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
Source: Neurological Sciences - Category: Neurology Source Type: research
Publication date: March 2018 Source:Biomedical Signal Processing and Control, Volume 41 Author(s): N. Tuğrul Artuğ, Imran Goker, Bülent Bolat, Onur Osman, Elif Kocasoy Orhan, M. Baris Baslo The present study aims to find new features that support the differential diagnosis of neuromuscular diseases. Scanning EMG is an experimental method developed for understanding the motor unit organization and for observing temporal and spatial characteristics of motor unit’s electrical activity. A motor unit consists of a motor neuron and muscle fibers that are innervated by its motor neuron. Both simulation and biologica...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Kim Landry-Truchon, Stephanie Fournier, Nicolas Houde, Jean-Philippe Rousseau, Lucie Jeannotte, and Richard Kinkead Fetal development of the respiratory tract and diaphragm requires strict coordination between genetically controlled signals and mechanical forces produced by the neural network that generates breathing. HOXA5, which is expressed in the mesenchyme of the trachea, lung and diaphragm, and in phrenic motor neurons, is a key transcription factor regulating lung development and function. Consequently, most Hoxa5–/– mutants die at birth from respiratory failure. However, the extensive effect of the nul...
Source: Journal of Experimental Biology - Category: Biology Authors: Tags: SHORT COMMUNICATION Source Type: research
The serotoninergic drug Lorcaserin rescued motor neuron electrophysiological abnormalities in an animal model of critical illness–induced weakness.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Editors ' Choice Source Type: research
Conclusions: The upgoing thumb sign is a subtle upper limb neurologic finding, with a high level of interobserver and intraobserver reliability. The test is easy to perform and can be interpreted accurately.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Research Source Type: research
Chronic traumatic encephalopathy (CTE) is the neurodegenerative disease of the moment, made famous by the violent and untimely deaths of many retired professional athletes. Repeated blows to the head sustained in contact sports such asboxing and American football can result in abnormal accumulations oftau protein (usually many years later). The autopsied brains from two of these individuals are shown below.Left: courtesy of Dr. Ann McKee inNYT. Right: courtesy of Dr. Bennett Omalu inCNN. These are coronal sections1 from the autopsied brains of: (L) Aaron Hernandez, aged 27; and(R) Fred McNeill, aged 63.Part 1 of this ...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
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