Characteristics of antimuscarinic responders versus suboptimal responders in a randomized clinical trial of patients with overactive bladder symptoms.

Characteristics of antimuscarinic responders versus suboptimal responders in a randomized clinical trial of patients with overactive bladder symptoms. Curr Med Res Opin. 2017 Jul 31;:1-19 Authors: Grenabo L, Herschorn S, Kaplan SA, Cardozo L, Scholfield D, Arumi D, Carlsson M, Chapman D, Ntanios F Abstract OBJECTIVE: To assess the characteristics of tolterodine extended-release (ER) 4 mg responders and suboptimal responders (≤50% decrease in UUI episodes/24 h) among patients with overactive bladder (OAB), including urgency urinary incontinence (UUI), and identify predictors of a>50% UUI response with fesoterodine 8 mg in tolterodine suboptimal responders. METHODS: Adult patients with OAB symptoms for ≥6 months and ≥8 micturitions, and ≥2 and
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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Conclusions: This study demonstrates that laser acupuncture can alleviate OAB symptoms and improve quality of life. This noninvasive device could be an effective therapy for women with OAB. PMID: 32419791 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Detrusor overactivity is an important urodynamic finding that has been shown to be present in women with severe symptom bother and to affect the treatment options and results. Objective and subjective clinical findings of overactive bladder syndrome were found to be more severe in women with detrusor overactivity [1]. The presence of preoperative detrusor overactivity was the only urodynamic finding that negatively affected the success of mid-urethral sling surgery [2]. Treatments such as Botulinum toxin A or neurostimulation are recommended for only in patients diagnosed with detrusor overactivity [3].
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research
Medications save lives and/or increase the quality of life for many people. Yet, there are few if any medications that have no side effects, many of which may negatively affect the brain or other organs of the body. In fact, the National Institutes of Health (NIH) says there is evidence that some overactive bladder medications (OBMs) can cause issues that are similar to Alzheimer’s and may, in some cases, even contribute to triggering symptoms. “Our study indicates an association between taking oxybutynin, solifenacin, and tolterodine and the subsequent diagnosis of dementia in DM patients. Moreover, the patien...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
CONCLUSION: Clinical presentation of MUS complications is heterogeneous. Surgical treatment was associated with low morbidity in our study. Post-operatively, half of the patients had SUI and a second MUS was a relevant treatment option after proper evaluation. LEVEL OF EVIDENCE: 4. PMID: 32409239 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Overactive bladder (OAB) is a bladder storage symptom-syndrome defined as “urinary urgency, usually accompanied by frequency and nocturia, with or without urge urinary incontinence (UUI), in the absence of urinary tract infection or other obvious pathology” [1]. OAB adversely affects daily activities, sleep, mental health, sexual function and general well-being of pat ients [2]. In fact, the negative impact on quality of life increases with the number of OAB symptoms and the psychological stress level [2,3].
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Review article Source Type: research
ConclusionsIn conclusion, imidafenacin was comparable to other ADs in the treatment of OAB. Moreover, imidafenacin presented a lower dry mouth rate, lower constipation rate and higher adherence and persistence.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
AbstractOveractive bladder syndrome (OAB) is defined as urinary urgency, usually with urinary frequency and nocturia, with or without urge urinary incontinence. The prevalence of OAB in adult women ranges between 11% and 42%, is particularly common in elderly people, and can overlap with the genitourinary syndrome of menopause (GSM). There is a wide approach to the treatment of symptoms, often in a stepwise fashion, including lifestyle changes, bladder retraining and pelvic floor muscle rehabilitation, drug therapy, intra-vesical botulinum toxin injections or neuromodulation. Recently, vaginal laser therapy has been propos...
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
In Reply In designing this trial, we sought to test 2 treatments with known effectiveness for urinary symptoms and implement them as one would in clinical practice. To optimize the drug therapy, we chose to use both an antimuscarinic and an α-adrenergic antagonist (α-blocker), based on evidence that using both drugs can yield better outcomes than either one alone. We had previously shown the behavioral intervention to be useful for urinary symptoms in men. The study objective was to determine whether combining behavioral and drug the rapies improves outcomes compared with each therapy alone for overactive bladd...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
A 69-year-old Asian man with a history of overactive bladder presented with postvoid dribbling and urinary incontinence in the past three years. He had cervical spinal stenosis surgery one month ago and two episodes of urinary tract infections with multidrug-resistant Escherichia coli species in urine culture in the last three months. Digital rectal examination revealed a 1-cm hard nontender nodule within the right side of his prostate, concerning for possible prostatic malignancy. Ultrasound study identified a hypoechoic area in the right lateral prostate. Serum prostate-specific antigen level was 2.03 ng/mL (reference ra...
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research
ConclusionsRates of UTI were similar in patients undergoing BTX and SNM. MDR UTI was rare. Patients with prior prolapse repair or recurrent UTI may be at a higher risk of UTI after either procedure.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
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