Polymorphism rs2073618 of the TNFRSF11B (OPG) Gene and Bone Mineral Density in Mexican Women with Rheumatoid Arthritis.

Polymorphism rs2073618 of the TNFRSF11B (OPG) Gene and Bone Mineral Density in Mexican Women with Rheumatoid Arthritis. J Immunol Res. 2017;2017:7680434 Authors: Nava-Valdivia CA, Saldaña-Cruz AM, Corona-Sanchez EG, Murillo-Vazquez JD, Moran-Moguel MC, Salazar-Paramo M, Perez-Guerrero EE, Vazquez-Villegas ML, Bonilla-Lara D, Rocha-Muñoz AD, Martín-Marquez BT, Sandoval-Garcia F, Martínez-García EA, Fajardo-Robledo NS, Ponce-Guarneros JM, Ramirez-Villafaña M, Alcaraz-Lopez MF, Gonzalez-Lopez L, Gamez-Nava JI Abstract Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and is influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 in the TNFRSF11B osteoprotegerin (OPG) gene has been related to postmenopausal OP although, to date, no information has been described concerning whether this polymorphism is implied in abnormalities of bone mineral density (BMD) in RA. We evaluated, in a case-control study performed in Mexican-Mestizo women with RA, whether SNP rs2073618 in the TNFRSF11B gene is associated with a decrease in BMD. RA patients were classified as follows: (1) low BMD and (2) normal BMD. All patients were genotyped for the rs2073618 polymorphism by PCR-RFLP. The frequency of low BMD was 74.4%. Higher age was observed in RA with low BMD versus normal BMD (62 and 54 years, resp.; p < 0.001). Worse functioning and lower BMI were observed in RA with low BMD (p = 0.003 and p = 0.002, resp....
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research