Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2

ConclusionsOur data indicate that leptin may enhance the proliferation, migration and invasion of breast cancer cells viaACAT2 up-regulation through the PI3K/AKT/SREBP2 signaling pathway. Therefore, the leptin/ACAT2 axis may represent an attractive therapeutic target for breast cancer, particularly in postmenopausal and/or obese women.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research