MD-17-0009 The PJ Nicholoff Steroid Protocol for Duchenne and Becker Muscular Dystrophy and Adrenal Suppression

Introduction Duchenne Muscular Dystrophy (DMD) is the most common and severe muscle disease presenting in childhood. It is caused by mutations in the dystrophin gene, located on the X chromosome, which causes a complete absence of dystrophin protein in muscle. Becker Muscular Dystrophy (BMD) is caused by partial absence of dystrophin; this disease is less severe and less common. As an X-linked disease, both diseases almost always affect males, though some females may be affected as well. Duchenne and Becker have a prevalence of 1 in 5000 males, in about a 2:1 ratio.1,2 People with Duchenne Muscular Dystrophy have progressive muscle weakness, which generally begins proximally and spreads to the legs, arms and other muscles. It is now known from a newborn screening study that the onset of disease is at birth, and probably in utero.3 Boys with Duchenne are born with serum creatine kinase (CK) values over 2000 U·L-1. The diagnosis is typically made between 3 and 5 years of age. Progressive muscle weakness leads to the loss of ambulation at 10 to 12 years old without treatment, though ambulation can be extended by one or two years through the use of corticosteroids. There is progressive respiratory muscle weakness, which leads to hypoventilation, respiratory insufficiency, and respiratory failure in adulthood. There is also a progressive cardiomyopathy leading to cardiac insufficiency. Prior to the use of corticosteroids, assisted ventilation and other interventions, the m...
Source: PLOS Currents Muscular Dystrophy - Category: Neurology Authors: Source Type: research

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https://www.citizen.org/wp-content/uploads/2497.pdf?eType=EmailBlastContent&eId=f75d6700-4f54-46af-97bd-4d025e1c1fdf&utm_campaign=pharmalittle&utm_source=hs_email&utm_medium=email&utm_content=79151431&_hsenc=p2ANqtz--o74l2DP24egS7LXZC1A0GDpunoC_ArHhPaMqDcQGBrF7vIXUBBT6LealdBe480MUKoSHc-jaPvcJPR1W-cPfMVpj5fA&_hsmi=79151431 "Public Citizen filed a... Should Tramadol Go Schedule II: Implications for Pain Patients
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Introduction Duchenne Muscular Dystrophy (DMD) is the most common and severe muscle disease presenting in childhood. It is caused by mutations in the dystrophin gene, located on the X chromosome, which causes a complete absence of dystrophin protein in muscle. Becker Muscular Dystrophy (BMD) is caused by partial absence of dystrophin; this disease is less severe and less common. As an X-linked disease, both diseases almost always affect males, though some females may be affected as well. DMD and BMD have a prevalence of 1 in 5000 males, in about a 2:1 ratio.1,2 People with Duchenne Muscular Dystrophy have progressive musc...
Source: PLOS Currents Muscular Dystrophy - Category: Neurology Authors: Source Type: research
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