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Headaches can be a warning sign of this rare type of cancer

CANCER can affect many different parts of the body - and even the ear. Symptoms of cancer of the middle and inner ear include headaches, tinnitus and dizziness.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Purpose of review: The aim of this review is to discuss how novel imaging modalities and molecular markers are shaping the definition of oligometastatic prostate cancer. Recent findings: To effectively classify a patient as having oligometastatic prostate cancer, diagnostic tests must be sensitive enough to detect subtle sites of metastatic disease. Conventional imaging modalities can readily detect widespread polymetastatic disease but do not have the sensitivity necessary to reliably classify patients as oligometastatic. Molecular imaging using both metabolic- and molecularly-targeted radiotracers has demonstrated great...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: CURRENT CONCEPTS IN OLIGO-METASTATIC DISEASE: Edited by Brian F. Chapin and Joaquim Bellmunt Source Type: research
Purpose of review: To examine the studies of prostate cancer biology, which evaluated oligometastatic and polymetastatic disease to identify data supporting differences between them. Recent findings: Studies of tumor biology suggest that malignant cells of limited metastatic potential exist, which may explain the phenomenon of oligometastatic disease. Conversely, oligometastatic disease may represent earlier presentation of polymetastatic disease in a proportion of cases. Data suggest molecular differences between oligo and polymetastatic disease, although larger studies are required to validate these results. Micro RNA d...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: CURRENT CONCEPTS IN OLIGO-METASTATIC DISEASE: Edited by Brian F. Chapin and Joaquim Bellmunt Source Type: research
Purpose of review: The oligometastatic disease state was initially described over 20 years ago as an ‘intermediate’ stage in metastatic cancer progression potentially amenable to curative treatment. Interest in identifying men with oligometastatic disease that may be cured has been increasing. However, whether there truly is a distinct oligometastatic state requires prospective validation, and a risk stratification system based on clinical and genomic factors is needed. Recent findings: We reviewed the existing literature, including 11 ongoing prospective clinical trials, defining the oligometastatic state. We...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: CURRENT CONCEPTS IN OLIGO-METASTATIC DISEASE: Edited by Brian F. Chapin and Joaquim Bellmunt Source Type: research
Purpose of review: To analyze recent trials of upfront chemotherapy to determine how this paradigm can be applied to oligometastatic prostate cancer patients. Recent findings: Upfront chemotherapy prolongs survival in metastatic prostate cancer, according to the ChemoHormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer and STAMPEDE docetaxel trials. However, the benefit is driven by the high volume subset and may not apply to low-volume/oligometastatic patients. Summary: Oligometastatic patients may not all share the same biology. Advanced imaging techniques may help to more...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: CURRENT CONCEPTS IN OLIGO-METASTATIC DISEASE: Edited by Brian F. Chapin and Joaquim Bellmunt Source Type: research
Purpose of review: Upfront docetaxel and androgen deprivation therapy (ADT) has improved outcomes over ADT alone in men with metastatic hormone-sensitive prostate cancer (mHSPC). Here in, we review the emerging role of novel androgen axis inhibitors in the treatment of men with mHSPC. Recent findings: Recently two studies, LATITUDE and STAMPEDE arm G, showed improved survival with addition of abiraterone acetate with prednisone or prednisolone to ADT in men with hormone-naïve advanced prostate cancer. Summary: Upfront docetaxel in addition to ADT has been shown to improve survival outcomes in men with high-volume mH...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: CURRENT CONCEPTS IN OLIGO-METASTATIC DISEASE: Edited by Brian F. Chapin and Joaquim Bellmunt Source Type: research
Purpose of review: Metastatic castration-resistant prostate cancer is in critical need of new and innovative treatment strategies. Since the approval of sipuleucel-T, the investigatory climate of prostate cancer immunotherapy has been rapidly evolving with promising developments in vaccine and immune checkpoint therapies. Recent findings: Sipuleucel-T remains the first and only therapeutic cancer vaccine approved for its survival benefit in metastatic castration-resistant prostate cancer. Additional cancer vaccines are currently being evaluated, with the most promising being a peptide vaccine encoding prostate-specific an...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: CURRENT CONCEPTS IN OLIGO-METASTATIC DISEASE: Edited by Brian F. Chapin and Joaquim Bellmunt Source Type: research
Purpose of review: Although cytoreductive surgery is accompanied with prolonged survival in many other malignancies in a metastatic stage, its role in oligometastatic prostate cancer is unclear. Recent findings: Radical prostatectomy (RP) in patients with oligometastatic prostate cancer seems to be feasible. Perioperative complication rates vary between 20 and 50% (Clavien 1–3) and are comparable to patients with locally advanced tumors. Postoperative functional outcomes (urinary continence and erectile function) can be slightly worse than in patients with locally advanced tumor. In literature, an oncological benefi...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: CURRENT CONCEPTS IN OLIGO-METASTATIC DISEASE: Edited by Brian F. Chapin and Joaquim Bellmunt Source Type: research
CONCLUSION: Radiation is a common component of treatment for head and neck cancers. The diagnosis of Eagle syndrome secondary to osteoradionecrosis of the styloid process is an elusive, but important, diagnosis to consider because the condition can be treated successfully. PMID: 28638295 [PubMed - in process]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
Conclusion Many people use medicines like paracetamol or ibuprofen for aches and pains. There's no suggestion from this study that occasional use to manage a headache or muscle strain is harmful. But the study is a reminder that regular use – defined by the researchers as two days or more a week – could have health consequences over time. However, this study has some limitations. As a cohort study, it can't prove cause and effect between paracetamol and NSAIDs and hearing loss. And it mainly included white women, all in the US, so we don't know if the results apply to other groups. Also, the increased risk ...
Source: NHS News Feed - Category: Consumer Health News Tags: Medication Source Type: news
Authors: Monzani D, Genovese E, Pini LA, DI Berardino F, Alicandri Ciufelli M, Galeazzi GM, Presutti L Abstract As L-type voltage-gated calcium channels (VGCCs) control Ca(2+) influx and depolarisation of cardiac and vascular smooth muscle, they represent a specific therapeutic target for calcium channel blockers (CCBs), which are approved and widely used to treat hypertension, myocardial ischaemia and arrhythmias. L-type currents also play a role in calcium entry in the sensory cells of the inner ear. In hair cells of both cochlea and labyrinth, calcium cytoplasmic influx is the first physiological process that ac...
Source: Acta Otorhinolaryngologica Italica - Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research
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