Long non-coding RNA NEAT1 promotes hepatocellular carcinoma cell proliferation through the regulation of miR-129-5p-VCP-I{kappa}B
This study provides new insights into the pathogenesis of HCC, as well as identifying new target genes for diagnosis and treatment.
NEW & NOTEWORTHY The results provide strong evidence that upregulated NEAT1 promotes the proliferation of cancer cells in hepatocellular carcinoma (HCC) and this regulatory mechanism depends on the microRNA (miR)-129-5p-valosin-containing protein-IB axis. The study also indicates that NEAT1 could be a potential therapeutic target for HCC.
Source: AJP: Gastrointestinal and Liver Physiology - Category: Gastroenterology Authors: Fang, L., Sun, J., Pan, Z., Song, Y., Zhong, L., Zhang, Y., Liu, Y., Zheng, X., Huang, P. Tags: RESEARCH ARTICLE Source Type: research
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