A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands

This study reports results on the functional significance of human NHE3-799C under basal conditions and in response to regulatory ligands, including a novel NHE3 inhibitor called tenapanor. We demonstrate that NHE3-799C is a common variant of NHE3 that is enriched in Asian populations; however, in contrast to our previous studies using rabbit NHE3, its presence seems to have limited clinical significance in humans and is not associated with compromised function or abnormal transport regulation.

Source: AJP: Gastrointestinal and Liver Physiology - August 1, 2017 Category: Gastroenterology Authors: Yin, J., Tse, C.-M., Cha, B., Sarker, R., Zhu, X. C., Walentinsson, A., Greasley, P. J., Donowitz, M. Tags: RESEARCH ARTICLE Source Type: research