Beyond immune thrombocytopenia: the evolving role of thrombopoietin receptor agonists

AbstractSince its discovery, the thrombopoietin (TPO) pathway has been an important pharmaceutical target for the treatment of thrombocytopenia. The first generation of TPO mimetics included peptide agents sharing homology with endogenous TPO, but these introduced a risk of antibody formation to endogenous TPO and were not successful. However, second-generation TPO mimetics or TPO receptor agonists (RAs) are currently being used to treat thrombocytopenia associated with a number of conditions, such as immune thrombocytopenia (ITP), severe aplastic anaemia (SAA), and hepatitis C virus-associated chronic liver disease. Accumulating efficacy and safety data suggest that the role of TPO-RAs in the treatment of thrombocytopenia may evolve in the near future with broader use of these agents in ITP and SAA, as well as approval in other indications, potentially including myelodysplastic syndromes, chemotherapy-associated thrombocytopenia, and post-transplant thrombocytopenia. This review provides an overview of clinical data on the efficacy and safety of TPO-RAs, emphasising recent findings that may expand their clinical utility.
Source: Annals of Hematology - Category: Hematology Source Type: research

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Gene therapy and gene editing (functional modification of genes) represent a future direction for treatment of human diseases. Viral vector-based gene delivery or gene transfer is crucial for this purpose. Thoracic and cardiovascular surgery provides great opportunities for translating experimental discoveries toward clinical applications. Awareness of the challenges and limitations of gene delivery is essential for clinician investigators in this field.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thoracic: Lung Transplant: Letter to the Editor Source Type: research
We read with great interest the article published by Oishi and colleagues,1 which reported that lentiviral-mediated interleukin-10 (IL-10) gene therapy decreased allograft lung rejection. We would like to congratulate Oishi and colleagues1 for this elegant study. In addition, we admire the work that has been done by that laboratory (led by Dr Keshavjee) regarding gene delivery in lung transplantation, and personally we2 share the overall enthusiasm of Oishi and colleagues.1 We would like to add several discussion points that we believe will increase the interest in this emerging topic.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thoracic: Lung Transplant: Letter to the Editor Source Type: research
AbstractBackgroundThe accuracy of diagnosis and clinical implications of the hepatoadrenal syndrome, as currently diagnosed using total cortisol, remain to be validated.AimThe aim of this study was to assess adrenal function using free cortisol in stable cirrhosis and study the potential implications of any abnormalities for renal and/or cardiac function.MethodsSixty-one stable consecutively enrolled patients with cirrhosis underwent assessment of adrenal function using the low-dose short Synacthen test, renal function by51Cr-EDTA glomerular filtration rate (GFR), and cardiac function by two-dimensional echocardiography.Re...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
AbstractPurposeHypomagnesemia is a common side effect of panitumumab. The effect of magnesium-containing supplement as a laxative and concomitant antacid (proton pump inhibitor and histamine H2 antagonist) administration on panitumumab-induced hypomagnesemia was retrospectively investigated.MethodsPatients with advanced or recurrent colorectal cancer who received panitumumab were included in this study. Serum magnesium levels were extracted from the electronic medical records of 1753 administrations in 221 patients who received panitumumab. Serum magnesium levels in patients with or without oral magnesium-containing supple...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
AbstractPlatinum-based drugs, mainly cisplatin, are used for the treatment of several solid tumors such as OS. However, cisplatin treatment often results in the development of chemoresistance, leading therapeutic failure. We have previously reported that platinum complexes containing 8-hydroxyquinoline ligands have good antitumor activity against different cancer cell lines and with a different and better cytotoxic profile than cisplatin. Here, the anticancer properties of two different quinoline –platinum complexes [Pt(Cl)2(quinoline)(dmso)] (1) [PtCl(8-O-quinoline)(dmso)] (2) on in vitro (2D and 3D) and in vivo mod...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
AbstractPurpose of reviewThis review aims to highlight recent research on the gut microbiome in IBD and the application of microbiome-modulating therapies for the treatment of IBD including the use of the microbiome as an indicator for disease severity and treatment response.Recent findingsDespite the high number of gut microbiome studies and emerging evidence supporting the gut microbiome ’s involvement in disease pathogenesis, no single microorganism has been identified as a pathogenic agent in IBD. Retrospective studies and meta-analyses on antibiotic use in ulcerative colitis and Crohn’s disease and long-te...
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
AbbVie Inc said on Friday its blockbuster cancer treatment in combination with chemotherapy agents failed to meet the main goal in a late-stage study of patients with a form of pancreatic cancer.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
AbbVie Inc said on Friday its cancer treatment in combination with chemotherapy agents failed to meet the main goal in a late-stage study of patients with a form of pancreatic cancer.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
We examined the association between albumin and hospital mortality in a cohort of 509 patients admitted for acute HF. None of the patients had infectious disease, severe arrhythmias (atrial fibrillation, ventricular tachycardia, ventricular fibrillation), required invasive ventilation or presented with acute coronary syndrome or primary valvular disease. Sixty-nine patients (14%) died during the 1-year follow-up. With multivariable analysis, haemoglobin level (p = .003), systolic blood pressure (p = .004) and serum albumin level (p = .003) emerged as independent predictors of long-...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Review in-depth clinical information, latest medical news, and guidelines on hepatitis B infection. Read the latest on prevention of hepatitis B virus with the hepatitis B vaccine.
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Resource Center Source Type: news
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