Fight Aging! Newsletter, July 31st 2017
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-earlier-stages-alzheimers-disease-blocks-rather-than-destroys-memories/ For years now, evidence has accumulated to suggest that Alzheimer's disease blocks memory retrieval rather than destroying memories, at least in the earlier stages prior to the onset of widespread destruction of neurons. Today's research is more of the same. This and related results raise the hope that success in any of the mainstream efforts to treat the causes of this disease should restore much of the cognitive function lost to the condition. Of course it is worth recalling that Alzheimer's patients rarely suffer Alzheimer's alone: it usually arrives alongside one or more other forms of neurodegeneration, each with distinct mechanisms that cause neurons to malfunction or be destroyed. This is in part because Alzheimer's disease is to some degree a lifestyle condition; not as grea...
Publication date: March–April 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 13, Issue 2Author(s): Mahdieh Sedighi Pashaki, Tayebeh Eghbali, Seyed Hassan Niksima, Ahmed N. Albatineh, Reza Ghanei GheshlaghAbstractHealth literacy is one of the most important determinants of health. Limited health literacy can leads to reduced adherence to treatment, repeated hospitalizations, and increased diseases complications. Several studies on health literacy among Iranian patients with type 2 diabetes have reported different prevalences of health literacy. The present study is aimed to determ...
Publication date: March 2019Source: Annals of Emergency Medicine, Volume 73, Issue 3Author(s): Ting-An Tung, Tou-Yuan Tsai
Publication date: March 2019Source: Annals of Emergency Medicine, Volume 73, Issue 3Author(s): Chih-Jen Yang, Chang-Chih Shih, Ching-Hsiang Lin
Publication date: March 2019Source: Annals of Emergency Medicine, Volume 73, Issue 3Author(s): M. Bryan Dalla Betta, Dasia Esener, J. Matthew Fields
Publication date: March 2019Source: Annals of Emergency Medicine, Volume 73, Issue 3Author(s): Heidi M. Goddard, Casey Z. MacVane, Tania D. Strout
Publication date: March 2019Source: Annals of Emergency Medicine, Volume 73, Issue 3Author(s): Po-Chen Chou, Shih-Chieh Chien
ConclusionImplementation of a HEART pathway in the ED evaluation of patients with chest pain resulted in less inpatient care and noninvasive cardiac testing and was safe. Using HEART to risk stratify chest pain patients can improve the efficiency and quality of care.
ConclusionAcute pain resolution after an ED visit seems to progress through 6 different trajectory patterns that are more informative than simple linear models and could be useful to adapt acute pain management in future research.
ConclusionA small proportion of ED patients discharged with nonspecific diagnoses of headache or back pain returned with a serious neurologic condition or inhospital death within 30 days.
Publication date: Available online 22 February 2019Source: SteroidsAuthor(s): Hye Joung Choi, Bao Ting ZhuAbstract2-Methoxyestradiol is an endogenous nonpolar metabolite of 17β-estradiol with a strong antitubulin activity. Earlier we showed that 2-methoxyestradiol increases the level and activity of cyclin B1/CDK1, which subsequently induces mitotic prometaphase arrest. In the present study, we demonstrate that upregulation of cyclin B1/CDK1 is responsible for the increased phosphorylation of the anti-apoptotic proteins Bcl-2 and Bcl-XL in 2-methoxyestradiol-induced, mitotically-arrested cancer cells. Additional analy...
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