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Significance of long chain polyunsaturated fatty acids in human health.

Significance of long chain polyunsaturated fatty acids in human health. Clin Transl Med. 2017 Dec;6(1):25 Authors: Zárate R, El Jaber-Vazdekis N, Tejera N, Pérez JA, Rodríguez C Abstract In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators. In this sense, new families of PUFA-derived lipid mediators, including resolvins derived from EPA and DHA, and protectins and maresins derived from DHA, are being increasingly investigated because of their active role in the "return to homeostasis" process and resolution of inflammation. Recent findings reviewed in the present study highlight that the omega-6 fatty acid ARA appears increased, and omega-3 EPA and DHA decreased in most cancer tissues compared to normal ones, and that increments in omega-3 LC-PUFAs consumption and an omega-6/omega-3 ratio of 2-4:1, are associated with a reduced risk of breast, prostate, colon and renal cancers. Along with their lipid-lowering prop...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Med Source Type: research

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This study explores how low-income rural Latino children and their mothers differ from their non-Latino white counterparts in terms of health, well-being, and health care access. A subsample of non-Latino white (n = 201) and Latino (n = 157) children and their mothers was drawn from the Rural Families Speak about Health Project, a multistate, cross-sectional data set developed through mixed purposive sampling methods. Findings suggest that Latino children's families were disadvantaged in terms of child health and access to health care, whereas non-Latino white children's families were disadvantaged in terms of child behavi...
Source: Family and Community Health - Category: Primary Care Tags: Original Articles Source Type: research
The purpose of this study is to examine expressed emotion and the relationship between expressed emotion and suicide probability in psychiatric outpatients (N = 350). Patients who did not receive support from anyone scored higher on the Level of Expressed Emotion (LEE) Scale than those who were supported by family, friends, or their physician provider. Scores by patients, who selected their spouse as a key person, scored higher on the LEE than those who chose one of their children. Spouses on the LEE were often depicted as being more intrusive, reactive, and intolerant when compared with their children. The probability of ...
Source: Family and Community Health - Category: Primary Care Tags: Original Articles Source Type: research
Erin Silverman, 35, of Potomac, Maryland, became a surrogate after her sister, Randi Fishman, 34, was diagnosed with breast cancer. Erin gave birth to her sister's baby in December.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A leader in IBM ’ s development of a speech-recognition system, she relied on her laptop to communicate after Lou Gehrig ’ s disease left her paralyzed.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Wolf, Catherine Deaths (Obituaries) Computers and the Internet Voice Recognition Systems Amyotrophic Lateral Sclerosis International Business Machines Corporation Source Type: news
Conclusions: An increased number of steps associated with FOG, which was elicited by the suddenly narrowed path, might be one predictor of an upgrade of stage in patients with Hoehn-Yahr stage III PD.Eur Neurol 2018;79:118 –124
Source: European Neurology - Category: Neurology Source Type: research
Abstract BackgroundThe platelet‐to‐lymphocyte ratio (PLR) has been found to predict clinical outcomes in borderline ovarian tumors and the other genital neoplasms. However, its prognostic value in patients with ovarian cancer remains controversial. The aim of this study was to assess its prognostic value in ovarian cancer. MethodsWe searched MEDLINE, EMBASE and the Cochrane databases to identify studies evaluating the prognostic significance of pretreatment PLR in ovarian cancer. The end points were overall survival (OS) and progression‐free survival (PFS). Pooled hazard ratios (HRs) with 95% confidence intervals (CI...
Source: European Journal of Clinical Investigation - Category: General Medicine Authors: Tags: Original Paper Source Type: research
This observational retrospective cross-sectional and case-controlled study measures levels of 25-hydroxy-vitamin D (25-OH-VD) in pediatric cancer survivors at different intervals and assesses the effect of 2 supplementation regimens over a period of 12 months. Sixty-eight patients were included in this quasi-experimental study, of which 32 were boys and 36 were girls. A control group of 30 healthy children were included. It was found that initial 25-OH-VD levels were insufficient (
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
This report documents the first observation of HLH associated with thyroid cancer, and illustrates the need to include imaging of the neck while evaluating patients with secondary HLH for an underlying malignancy.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Conclusions: Our data demonstrate that a significant number of children lose preexisting humoral immunity against MMR and hepatitis B after completion of chemotherapy.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
This study examined the prevalence of depressive symptoms and suicidal ideation among 220 first year undergraduate university students in Ireland. Data were collected using the Centre for Epidemiological Studies Depression Scale and the Suicidal Behaviours Questionnaire. Findings indicated that 59% of participants experienced depressive symptoms and 28.5% had suicidal ideation. Financial stress and poor relationships with both parents, increased the odds of experiencing depressive symptoms. Sexual orientation, financial stress, and poor relationships with fathers, increased the odds of experiencing suicidal ideation. Suici...
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
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