The influence of functional groups on the permeation and distribution of antimycobacterial rhodamine chelators.
The influence of functional groups on the permeation and distribution of antimycobacterial rhodamine chelators. J Inorg Biochem. 2017 Jul 22;175:138-147 Authors: Moniz T, Leite A, Silva T, Gameiro P, Gomes MS, de Castro B, Rangel M Abstract We formerly hypothesized a mechanism whereby the antimycobacterial efficiency of a set of rhodamine labelled iron chelators is improved via the rhodamine fluorophore which enhances the chelators' permeation properties through membranes. To validate our hypothesis in a cellular context and to understand the influence of the structure of the fluorophore on the chelator's uptake and distribution within macrophages we now report comparative confocal microscopy studies performed with a set of rhodamine labelled chelators. We identify the functional groups of the chelator's framework that favor uptake by macrophages and conclude that the antimycobacterial effect is strongly related with the capacity of the chelator to distribute within the host cell and its compartments, a property that is closely related with the chelators' ability to interact with membranes. The quantification of the chelators' interaction with membranes was assessed through measurement of the corresponding partition constants in liposomes. The overall results support that the compounds which are preferentially taken up are the most efficient antimycobacterial chelators and for that reason we infer that the biological activity is modulated by the structur...
Authors: Khurram A, Abedi D, Abedi M PMID: 32497473 [PubMed - as supplied by publisher]
CONCLUSION: Use of VR facility tours as an alternative to in-person tours of affiliate training facilities during a residency interview day is a viable and innovative option that can save time and money and favorably impact the applicant's impression of the program. More research is necessary to assess whether VR tours can replace in-person tours at the main teaching site, however, while social distancing measures are in place, VR tours may become necessary for programs moving forward. ABBREVIATIONS: Med-Peds: Internal Medicine-Pediatrics; VR: Virtual Reality; AAMC: Association of American Medical Colleges; IRB: Instit...
Authors: Edigin E, Eseaton PO, Shaka H, Ojemolon PE, Asemota IR, Akuna E PMID: 32493181 [PubMed - in process]
Authors: Roberts V, Malone K, Moore P, Russell-Webster T, Caulfield R Abstract Our personal views about the challenges of continuing to deliver peer teaching during a pandemic. We are a group of 4th year medical students who are part of a student society which has delivered structured, highly formulaic peer-led teaching sessions for the past three years. During the COVID-19 pandemic, the reduced access to our normal clinical teaching highlighted the importance of peer-led teaching sessions. We wanted to continue with our peer-taught sessions but knew we would have to devise a new format to make our teaching accessi...
Publication date: Available online 5 June 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chih-Cheng Lai, Cheng-Yi Wang, Wen-Chien Ko, Po-Ren Hsueh
Publication date: Available online 4 June 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Huei-Hsuan Chiu, Huai-Lei Juan, Po-Liang Lu, Ko Chang
Publication date: Available online 5 June 2020Source: Journal of Microbiological MethodsAuthor(s): Laura Villa, Aurora Torreblanca, Luis Otero, Francisco Carreño, Rainer Campo, María López-Escobar, Fernando Vazquez
Publication date: Available online 5 June 2020Source: Journal of Microbiological MethodsAuthor(s): Dennis L. Welker, Bailey L. Crowley, Justin B. Evans, Martin H. Welker, Jeff R. Broadbent, Robert F. Roberts, David A. Mills
Publication date: Available online 4 June 2020Source: Statistics &Probability LettersAuthor(s): Mohamed Marzougue
Publication date: December 2020Source: Physics of the Dark Universe, Volume 30Author(s): F.D. Villalba, P. Bargueño, A.F. Vargas, E. Contreras