Real-World Economic Burden Associated with Transplantation-Related Complications
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for patients with high-risk hematologic malignancies [1,2]. Common indications for HCT in adults include acute myelogenous leukemia, myeloproliferative neoplasms, myelodysplastic syndromes, chronic myelogenous leukemia, chronic lymphocytic leukemia, acute lymphoblastic leukemia, lymphoma, multiple myeloma, Hodgkin lymphoma, non-Hodgkin lymphoma, and certain solid tumors .
Aneurysms of the renal arteries are rare, probably under-diagnosed, with an incidence estimated at 0.01%. A size exceeding 20mm and the presence of symptoms such as hypertension represent a therapeutic indication for most authors. Endovascular techniques are used more and more to treat proximal lesions and auto-transplantation is the technique of reference for intra-parenchymatous lesions. However, most hilar, non-intra-parenchymatous lesions can be treated in situ without cooling and with a reasonable clamping time.
The objective of this work was to study the mid-term results of the angioplast y of the renal artery on transplanted kidneys.
Abstract: Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Immunohistochemical staining with anti-c-CBL antibody was performed on lesional biopsies from a total of 65 patients with atopic dermatitis, allergic contact der...
Abstract: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) represents approximately 20% of cutaneous B lymphomas with an intermediate prognosis. Spontaneous regression is uncommon; there are only 2 published cases. An 83-year-old woman presented 2 orange erythematous nodules on the back of her right leg with an elastic consistency, infiltrated, painful to the touch, and of an 8-month evolution. A histological examination revealed a dense cellular dermo-hypodermic infiltrate sparing the papillary dermis, composed of large cells with immunoblast and centroblast morphology and frequent mitosis. Immunohis...
Conclusion: This case may illustrate a resemblance in the renal glomerulus basement membrane and retinal pigment epithelium–Bruch membrane complex, because the authors observed deposits of excess monoclonal kappa chains manifesting as extracellular, proteinaceous aggregates on the basement membrane of the glomerulus, and striking, globular subretinal deposits that overlay a thickened retinal pigment epithelium–Bruch membrane complex. The ocular lesions' refractoriness to intravitreal treatments could be attributed to the fact that they represent proteinaceous aggregates similar to those documented in the glomer...
Continuous-flow ventricular assist devices (CF-VAD) have been widely used in end-stage heart failure in adult patients for both bridge to transplantation and destination therapy. Technology improvement has enabled miniaturization of the CF-VAD, which may greatly benefit the pediatric patients with sufficient body size in advanced heart failure. There are still, however, challenging situations for CF-VAD implantation, such as in single ventricle physiology, anatomically abnormal heart, small children and infants.
Background: Severe heart failure (HF) patients often have renal dysfunction because of low cardiac output. Methods and Results: 39 patients underwent a centrifugal-type, continuous-flow left ventricular assist device (LVAD) (EVAHEART) implantation as a bridge to cardiac transplantation at our institute between 2005 and 2015. We investigated the changes in renal function over 2 years among 36 patients with supported by EVAHEART over 6 months. The median estimated glomerular filtration rate (eGFR) at implantation was 62 ± 32 mL/min/1.73 m2 and 47% of the patients showed eGFR
This study tested the hypothesis that renal transplantation (RT) leads to improvement of LV remodeling/function. Methods: A total of 48 ESRD patients were divided into two groups: recipients who underwent RT (RT; n = 28) and hemodialysis continuation patients (HD; n = 20).
Heart failure syndrome (HF) is one of the major public health concerns, since the number of aged people who are susceptible for HF are increasing and donor supply for cardiac transplantation is limited in Japan. Several clinical trials have established that beta-adrenergic receptor blockers are most useful in prolonging life expectancy in general population of HF in addition to renin-angiotensin system blockade. However, several problems remain to be solved. HF is accompanied by multiple comorbidities, especially in elderly patients.
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