PodMed – Week of July 31, 2017

This week’s topics include football and CTE, discontinuing statins, intramuscular HIV meds, and long term risks of stroke and TIA. Program notes: 0:32 Stroke and TIA risk 1:35 Adverse outcomes five years later 2:35 Be aggressive about managing risk 3:24 Statin discontinuation risk 4:24 Those who continued 12% had a stroke 5:25 Driven by internet […]
Source: Johns Hopkins Medicine Weekly Health News - Category: Consumer Health News Authors: Tags: All Podcasts Chronic Disease HIV Infectious diseases Nervous System Disorders Neurology And Neurosurgery PodMed Source Type: podcasts

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Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Jenq-Lin Yang, Yun-Ru Yang, Shang-Der ChenAbstractStroke is the major cause of adult disability and the second or third leading cause of death in developed countries. The treatment options for stroke (thrombolysis or thrombectomy) are restricted to a small subset of patients with acute ischemic stroke because of the limited time for an efficacious response and the strict criteria applied to minimize the risk of cerebral hemorrhage. Attempts to develop new treatments, such as neuroprotectants, for acute ischemic stroke have been costly and tim...
Source: Life Sciences - Category: Biology Source Type: research
Postoperative pulmonary embolism risk still elevated 7-12 weeks later, regardless of the type of procedure Related items fromOnMedica Prescribe higher dose opioids for shorter time after surgery Poor pain management - a major cause of opioid crisis Statin use after stroke not linked to bleeds Don ’t delay young children’s surgery for fear of GA harms Earlier thrombolysis improves stroke outcomes
Source: OnMedica Latest News - Category: UK Health Source Type: news
This study aimed to investigate the impact of clinical pharmacist intervention on the prognosis of acute coronary syndrome (ACS) in Chinese patients with CHD. Two hundred and forty patients who had ACS were recruited. Participants were randomly assigned to the intervention group (n = 120) or the control group (n = 120). The intervention group received a medication assessment and education by the clinical pharmacist at discharge and telephone follow-ups at 1 week and 1 and 3 months after discharge. The control group received usual care. The primary outcomes of this study were the proportion of patients who had major adverse...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, the most common reason that patients or their doctors stopped statins was the development of advanced cancer or other major illness. In my practice, I have also cared for many patients who have stopped taking statins or who express reluctance to take statins due to side effects. The most common side effect is muscle ache (typically tenderness or soreness of the large muscle groups, such as the biceps and thighs), which affects about 20% of statin takers and reverses when the statin is discontinued. There is also a slightly increased risk of diabetes with long-term statin use and, very rarely, liver problems....
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Healthy Aging Heart Health Source Type: blogs
CONCLUSIONS: Pravastatin significantly reduced the recurrence rate of all stroke among patients with PCS. Thus, the effect of statin on the recurrence of stroke may differ according to infarction location. PMID: 31554765 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Title: AHA News: Why Aren't More Stroke Survivors Getting Statins?Category: Health NewsCreated: 9/26/2019 12:00:00 AMLast Editorial Review: 9/27/2019 12:00:00 AM
Source: MedicineNet Heart General - Category: Cardiology Source Type: news
Abstract Statins are long known class of medicines and the most frequently prescribed drugs in cardiovascular pharmacotherapy, widely ordered not only in patients suffering from dyslipidemia, but also in patients with coronary artery disease, acute coronary syndromes, diabetes mellitus, stroke, hypertension, and chronic kidney disease, with or without coexisting dyslipidemia. However, several clinical trials have shown, that the advantages of statins goes beyond their reduction of the cholesterol level. Some crucial isoprenoid mediators which are highly essential for the activation of different intracellular/signa...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
THURSDAY, Sept. 26, 2019 (American Heart Association News) -- People with a history of stroke are less likely than those with heart disease to get cholesterol-lowering statin drugs despite the benefits, a new study has found. Statins help protect...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Increasing evidence suggests a role for endothelial cell (EC) dysfunction in pathogenesis of cerebral small vessel disease. Commonly used medications including certain antihypertensives and statins have EC-stabilizing effects. We used individual patient data from completed acute stroke trials to assess whether prior exposure to EC-stabilizing medications was associated with lacunar stroke, using lacunar stroke as a clinical proxy for cerebral small vessel disease. Across 12,002 patients with relevant data, 2,855 (24%) had a lacunar stroke presentation. Univariable analyses suggested potential confounding from vascular dise...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSIONS: Statins showed different influences on the risks of atherothromobotic and lacunar stroke according to postrandomized LDL cholesterol levels. PMID: 31534062 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
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