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Boston Scientific warns on fluke S-ICD death

Boston Scientific (NYSE:BSX) last month alerted physicians after learning of a fluke incident involving its S-ICD pacemaker, in which a patient died when the device’s memory was corrupted by radiation. In a June letter to physicians, Marlborough, Mass.-based Boston Scientific wrote of “a single, isolated S-ICD event that resulted in a device-related patient death in May of this year.” “Boston Scientific engineers have determined that this patient’s S-ICD repeatedly delivered an atypical amount of energy (similar to the arrhythmia induction function) because a specific memory location was corrupted by radiation within the environment. This repeated atypical energy delivery prevented S-ICD arrhythmia detection/treatment and ultimately contributed to the patient death,” according to the letter, which noted that the radiation involved in the incident was from an ionized subatomic particle such as an alpha particle, neutron, or high energy proton – although it does not appear that the deceased patient received ionizing radiation therapy prior to the event. A three-week internal investigation in the lab, including experiments to simulate the issue, led Boston engineers to conclude that the incident was a one-off – a so-called “single event upset” involving “a change of state in the device memory induced by environmental radiation interacting with a specific memory location,” with a probability of appr...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiovascular Wall Street Beat Boston Scientific Cardiac Rhythm Management Source Type: news

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ANISH KOKA, MD There are 80,000 new cases of primary brain tumors diagnosed every year in the United States.  About 26,000 of these cases are of the malignant variety – and John McCain unfortunately joined their ranks last week.  In cancer, fate is defined by cell type, and the adage is of particular relevance here. Cancer is akin to a mutiny arising within the body, formed of regular every day cells that have forgotten the purpose they were born with. In the case of brain tumors, the mutinous cell frequently happens to not be the brain cell, but rather the lowly astrocyte that normally forms a matrix ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Physicians Anish Koka John McCain Source Type: blogs
ANISH KOKA, MD There are 80,000 new cases of primary brain tumors diagnosed every year in the United States.  About 26,000 of these cases are of the malignant variety – and John McCain unfortunately joined their ranks last week.  In cancer, fate is defined by cell type, and the adage is of particular relevance here. Cancer is akin to a mutiny arising within the body, formed of regular every day cells that have forgotten the purpose they were born with. In the case of brain tumors, the mutinous cell frequently happens to not be the brain cell, but rather the lowly astrocyte that normally forms a matrix ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Physicians Anish Koka John McCain Source Type: blogs
Radiation therapy for breast cancer increases the risk of long term cardiac morbidity, but modern techniques may decrease this risk. This work presents secondary analyses of cardiac outcomes from the control arm of BCIRG-001. We find an increase in arrhythmias but no significant increase in the risk of MI and CHF at 10 years in LN positive women treated with breast RT and uniform adjuvant doxorubicin-based chemotherapy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
This article reviews the pathogenesis and prevention of radiation-induced myocardial fibrosis for providing references for the prevention and treatment of radiation-induced myocardial fibrosis. PMID: 28440606 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusions— Single-fraction doses as low as 25 Gy caused a lesion with interruption of cardiac impulse propagation using this respective target volume. With doses of ≤55 Gy, maximal point-doses to coronary arteries could be kept
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Translational Studies Original Article Source Type: research
Abstract Cardiotoxicity from chemotherapy is a leading cause of morbidity and mortality in cancer survivors. Cardiotoxic effects include left ventricular systolic dysfunction, coronary artery disease, hypertension, bradycardia, arrhythmias, pericardial disease, valvular disease, and radiation-induced restrictive cardiomyopathy. Noninvasive cardiac imaging has been at the forefront of detecting cardiotoxicity in patients receiving chemotherapeutic agents known to adversely affect cardiac structure and function. Regimens for cardiotoxicity surveillance prior to and during chemotherapy administration have been proposed; howe...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Conclusions Rates of anesthetic complications encountered in pediatric radiation therapy are similar, if not lower, than rates reported in controlled operating room settings, implying that anesthesia for pediatric radiation therapy is safe, with low complication rates periprocedurally. Propofol infusion and oxygen delivery via nasal cannula offer the lowest immediate anesthetic complication rates and are hence most recommended for use. Though the long-term neurocognitive consequences of multiple anesthetics in pediatric patients have yet to be clearly defined, health care providers should be cognizant of the potentially serious implications.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
The post below first appeared on HuffPost Healthy Living on April 20. Jen Hyde, a 30-year-old poet and artist living in Brooklyn, has a congenital heart defect. By the age of 25, Hyde had two open-heart surgeries, including a heart valve replacement. “I know that heart disease is the number one killer of women in America,” Hyde said. “I’m currently in great shape, but part of staying this way means building a strong relationship with my cardiologist so that the care I receive is preventative, not reactive.” Hyde is not alone in suffering from heart health issues — in the U.S., cardiova...
Source: Disruptive Women in Health Care - Category: Consumer Health News Authors: Tags: Chronic Conditions Source Type: blogs
Abstract Radiation therapy is an important component of cancer treatment, and today, it is applied to approximately 50 % of malignancies, including valvular, myocardial, pericardial, coronary or peripheral vascular disease, and arrhythmias. An increased clinical suspicion and knowledge of those mechanisms is important to initiate appropriate screening for the optimal diagnosis and treatment. As the number of cancer survivors has been steadily increasing over the last decades, cardio-oncology, an evolving subspecialty of cardiology, will soon play a pivotal role in raising awareness of the increased cardiovas...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Background: Radiation therapy is a key component in the treatment of breast cancer. Recent studies have attempted to detail the potential impact that radiation may have on the development of cardiovascular complications in patients with breast cancer. The results of these studies, however, are conflicting regarding the magnitude and clinical significance of the cardiovascular effects with the use of modern radiation techniques. The aim of our study was to examine cardiovascular outcomes in breast cancer patients who received radiation therapy compared to those who did not. Methods: After IRB approval, all breast cancer pat...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
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