Immune cell profile of dental pulp in rats treated with zoledronic acid
The objective of this study was to characterize the pulp immune cell profile in the teeth of rats treated with Zoledronic Acid (ZA). For this Male Wistar rats (n=6) received 4 intravenous infusions of ZA (0.04, 0.20 or 1.00 mg/kg) or saline. In the 70th day, they were euthanized. The first right molar was microscopically examined (H&E, toluidine blue and immunohistochemistry for CD68, Tumor Necrosis Factor (TNF)- α, Interleukin(IL)-1β, Inducible Nitric Oxide Synthase (iNOS), Nuclear Factor kappa B (NFkB) and IL-18 binding protein (IL-18bp).
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: PAULO GOBERL ÂNIO DE BARROS SILVA, MARIA ELISA QUEZADO LIMA VERDE, ANTONIO ERNANDO CARLOS FERREIRA JUNIOR, CAMILA CARVALHO DE OLIVEIRA, FABRÍCIO BITÚ SOUSA, MÁRIO ROGÉRIO LIMA MOTA, ANA PAULA NEGREIROS NUNES ALVES Tags: RP - Research Poster Source Type: research