The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability

ConclusionThis study demonstrates that the T78M cav-3 induces complex modifications in ion channel function that ultimately alter membrane excitability. The presence of the T78M cav-3 can thus generate a susceptible substrate that, in concert with other structural alterations and/or genetic mutations, may become arrhythmogenic.
Source: Cardiovascular Research - Category: Cardiology Source Type: research