Disease sleuths unmask deadly encephalitis culprit

Source: ScienceNOW - Category: Science Authors: Tags: Asia/Pacific News, Epidemiology, Medicine, Diseases, Virology In Depth Source Type: news

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Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): M.P. Dagleish, J.J. Clark, C. Robson, M. Tucker, R.J. Orton, M.S. RocchiSummaryLouping-ill (LI), caused by louping-ill virus (LIV), results in a frequently fatal encephalitis primarily affecting sheep and red grouse (Lagopus lagopus scotica), but it does occur in other species. An adult male Border collie dog was definitively diagnosed with fatal LI and the lesion profile, LIV antigen distribution and full genome sequence of the LIV responsible were investigated to determine if this differed significantly from sheep-derived LIV. N...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease. Oncotarget. 2018 Sep 21;9(74):33884-33895 Authors: Hayrabedyan S, Todorova K, Spinelli M, Barnea ER, Mueller M Abstract The central pathological feature of Alzheimer's disease (AD) is the sequential proteolytic processing of amyloid precursor protein (APP) to amyloid-β peptides (Aβ) agglomeration. The clearance of Aβ may be induced by the large zinc-binding protease insulin degrading enzyme (IDE). IDE is the common link between AD and Type II diabetes as ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This report summarizes surveillance data reported to CDC from U.S. states in 2017 for nationally notifiable arboviruses. It excludes dengue, chikungunya, and Zika viruses because, in the continental United States, these viruses are acquired primarily through travel. In 2017, 48 states and the District of Columbia (DC) reported 2,291 cases of domestic arboviral disease, including 2,097 (92%) WNV disease cases. Among the WNV disease cases, 1,425 (68%) were classified as neuroinvasive disease (e.g., meningitis, encephalitis, or acute flaccid paralysis), for a national rate of 0.44 cases per 100,000 population. More Jamestown ...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Conditions:   Meningitis;   Encephalitis;   Guillain-Barré;   Subarachnoid Hemorrhage;   Intracranial Neoplasm;   Intracranial CNS Disorder Intervention:   Device: LPat Device Sponsors:   Spartanburg Regional Healthcare System;   Edward Via Virginia College of Osteopathic Medicine Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report the case of a pregnant female presenting with behavioral change and hallucinations followed by focal seizures with impaired awareness. EEG revealed generalized slowing interspersed with extreme delta-brush pattern and MRI brain was normal. Both Serum and CSF anti-N-methyl-d-aspartate receptor (NMDAR) antibodies were positive. Patient had a prolonged hospital stay with full recovery and delivered a healthy baby, highlighting the significance of early diagnosis and management in this disorder.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Tags: Short Communication Source Type: research
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for a variety of benign and malignant hematologic and immunologic conditions. Despite diagnostic and therapeutic advances in the management of post-HCT opportunistic infections, human cytomegalovirus (CMV) remains associated with significant morbidity, organ toxicity, and transplant-related mortality.1-3 Uncontrolled CMV infection can lead to pneumonitis or enterocolitis, and more rarely hepatitis, retinitis, and encephalitis.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
NMDA-receptor antibodies (NMDAR-Abs) cause an autoimmune encephalitis with a diverse range of EEG abnormalities. NMDAR-Abs are believed to disrupt receptor function, but how blocking this excitatory synaptic receptor can lead to paroxysmal EEG abnormalities—or even seizures—is poorly understood. Here we show that NMDAR-Abs change intrinsic cortical connections and neuronal population...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
Abstract Herpes simplex virus type-1 (HSV-1) is a ubiquitous pathogen that infects a large majority of the human population worldwide. It is also a leading cause of infection-related blindness in the developed world. HSV-1 infection of the cornea begins with viral entry into resident cells via a multistep process that involves interaction of viral glycoproteins and host cell surface receptors. Once inside, HSV-1 infection induces a chronic immune-inflammatory response resulting in corneal scarring, thinning and neovascularization. This leads to development of various ocular diseases such as herpes stromal keratiti...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
Enterovirus A71 (EV-A71) receptors that have been identified to date cannot fully explain the pathogenesis of EV-A71, which is an important global cause of hand, foot, and mouth disease and life-threatening encephalitis. We identified an IFN-γ–inducible EV-A71 cellular entry factor, human tryptophanyl-tRNA synthetase (hWARS), using genome-wide RNAi library screening. The importance of hWARS in mediating virus entry and infectivity was confirmed by virus attachment, in vitro pulldown, antibody/antigen blocking, and CRISPR/Cas9-mediated deletion. Hyperexpression and plasma membrane translocation of hWARS were obs...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In conclusion, we demonstrated a simple generation-dependent model that was able to adequately capture an observed transmission pattern of the measles outbreak in Japan, 2018. The proposed model also helped predict the future incidence and evaluate public health control measures. Polishing the forecasting model further, we can achieve an eventual routine forecast and evaluation the outbreaks while maintaining the model structure as simple as possible. Competing Interests The authors declare no competing interests. Data Availability The code snippets used for simulations and generation of figures as well as the epidemiolo...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
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