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Disease sleuths unmask deadly encephalitis culprit

Source: ScienceNOW - Category: Science Authors: Tags: Asia/Pacific News, Epidemiology, Medicine, Diseases, Virology In Depth Source Type: news

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Early establishment of infectious processes allows for expedited clinical management of meningitis and encephalitis. The FilmArray meningitis/encephalitis (FA-M/E) panel provides rapid detection of potential pathogens associated with encephalitis/meningitis in both immunocompetent and compromised patients. Here, we conducted a 1-year review of the performance of the FA-M/E panel at a tertiary care children's hospital. Two hundred sixty-five samples from 251 patients were tested. We found 87.25% (219/251) were negative, 9.96% (25/251) were positive for viral analytes, and 3.19% (8/251) were positive for bacterial analytes. ...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Bacteriology Source Type: research
AbstractWest Nile Virus (WNV) can be a neuroinvasive pathogen that may produce persistent mild-to-moderate neurocognitive impairments in some infected persons. Intra-individual variability (IIV) is an index of a person ’s performance across a neuropsychological test or battery, which is an indicator of neurocognitive control and integrity of prefrontal systems. The present study examined possible associations of IIV to neurological health and well-being in WNV infection. Participants included 84 adults with a ra nge of clinical WNV disease (31 West Nile Encephalitis, 16 West Nile Meningitis, 37 West Nile Fever) who c...
Source: Journal of NeuroVirology - Category: Neurology Source Type: research
To determine the associated cost related to diagnosis and treatment of meningoencephalitis (ME) in adult patients in the United States.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Japanese encephalitis (JE), caused by a mosquito-borne flavivirus, is an acute central nervous system infection. An estimated 68,000 cases are reported globally each year, mostly among children [1]. JE is reported commonly in Southern and Eastern Asia including China, Nepal and India. There is no treatment for JE. Vector-control measures are not operationally feasible, are costly and of limited value [2]. It causes significant illness with mortality in almost one-third and similar number of recovered patients experience disability [3].
Source: Journal of Infection and Public Health - Category: International Medicine & Public Health Authors: Source Type: research
Discussion Normal kidneys regulate water balance to maintain a plasma osmolality of 275-290 mOsm/kg normally. Thirst and arginine vasopressin or antidiuretic hormone (ADH) are the primary regulators of plasma osmolality. ADH is made in the hypothalamus and released by the posterior pituitary gland. ADH acts on the kidney’s distal collecting duct to increase water reabsorption. ADH is appropriately released in hypovolemic states, such as dehydration caused by gastroenteritis. ADH has an ~10 minute half-life and therefore can respond to rapid changes in volume status. Sodium balance is regulated by aldosterone (as part...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
AbstractViral infection of the central nervous system can result in encephalitis. About 20% of individuals who develop viral encephalitis go on to develop epilepsy. We have established an experimental model where virus infection of mice with Theiler ’s murine encephalomyelitis virus (TMEV) leads to acute seizures, followed by a latent period (no seizures/epileptogenesis phase) and then spontaneous recurrent seizures—epilepsy. Infiltrating macrophages (CD11b+CD45hi) present in the brain at day 3 post-infection are an important source of interleukin-6, which contributes to the development of acute seizures in the...
Source: Journal of NeuroVirology - Category: Neurology Source Type: research
Annals of Neurology,Volume 83, Issue 4, Page 863-869, April 2018.
Source: Annals of Neurology - Category: Neurology Authors: Source Type: research
N Shah, AV Nair, S Ahamed, KS ManojJournal of Postgraduate Medicine 2018 64(2):127-127
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
Publication date: Available online 18 April 2018 Source:Epilepsy & Behavior Case Reports Author(s): Nikolai Gil D. Reyes, Mario B. Prado, Christian Wilson R. Turalde, Marc Laurence L. Fernandez
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research
Authors: Carod-Artal FJ Abstract INTRODUCTION: Zika virus (ZIKV) disease is a vector-borne infectious disease transmitted by Aedes mosquitoes. Recently, ZIKV has caused outbreaks in most American countries. Areas covered: Publications about neurological complications of ZIKV infection retrieved from pubmed searchers were reviewed, and reference lists and relevant articles from review articles were also examined. Vertical/intrauterine transmission leads to congenital infection and causes microcephaly and congenital ZIKV syndrome. ZIKV preferentially infects human neural progenitor cells and triggers cell apoptosis. ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
More News: Encephalitis | Epidemiology | Virology