Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome.

Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome.
Behav Brain Res. 2017 Jul 22;:
Authors: Corrales A, Parisotto EB, Vidal V, García-Cerro S, Lantigua S, Diego M, Filho DW, Sanchez-Barceló EJ, Martínez-Cué C, Rueda N
Abstract
Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome. Here, we investigated the effects of pre- and post-natal melatonin treatment on behavioral and cognitive abnormalities and on several neuromorphological alterations (hypocellularity, neurogenesis impairment and increased oxidative stress) that appear during the early developmental stages in TS mice. Pregnant TS females were orally treated with melatonin or vehicle from the time of conception until the weaning of the offspring, and the pups continued to receive the treatment from weaning until the age of 5 months. Melatonin administered during the pre- and post-natal periods did not improve the cognitive impairment of TS mice as measured by the Morris Water maze or fear conditioning tests. Histological alterations, such as decreased proliferation (Ki67+ cells) and hippocampal hypocellularity (DAPI+ cells), which are typical in TS mice, were not prevented by melatonin. However, melatonin partially regulated brain oxidative str...

Source: Behavioural Brain Research - July 22, 2017 Category: Neurology Authors: Corrales A, Parisotto EB, Vidal V, García-Cerro S, Lantigua S, Diego M, Filho DW, Sanchez-Barceló EJ, Martínez-Cué C, Rueda N Tags: Behav Brain Res Source Type: research