llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause.

llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause. Exp Gerontol. 2017 Jul 21;: Authors: Pereira CS, Stringhetta-Garcia CT, da Silva Xavier L, Tirapeli KG, Pereira AAF, Kayahara GM, Tramarim JM, Crivelini MM, Padovani KS, Leopoldino AM, Louzada MJQ, Belló-Klein A, Llesuy SF, Ervolino E, Dornelles RCM, Chaves-Neto AH, de Melo Stevanato Nakamune AC Abstract During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16months) in proven perimenopause period received 20mg/kgBW/day of mate tea, by gavage (PM+MT Group, n=10) or water (PM Group, n=10). Female rats aged 4months (AD Group, n=10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of oste...
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research