The Risk of Major NSAID Toxicity with Celecoxib, Ibuprofen or Naproxen: a Secondary Analysis of the PRECISION Randomized Controlled Clinical Trial

• Naproxen and ibuprofen at moderate dosages were associated with significantly more major NSAID toxicity events than celecoxib among older adults with arthritis and established coronary artery disease or risk factors.• These risks translate into numbers needed to harm of 135 (95% CI 72-971) for naproxen and 82 (95% CI 53-173) for ibuprofen, both compared with celecoxib.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Research Study Source Type: research