Grad Student Profile – Morgan Gilman: Embracing Opportunity

Morgan Gilman, a fourth-year graduate student in the McLellan Lab at Geisel, is helping lead efforts to understand how a particular type of protein allows deadly viruses—such as Ebola and RSV (respiratory syncytial virus)—to gain entry into host cells, and how antibodies can be developed to neutralize that process.
Source: News at Dartmouth Medical School - Category: Hospital Management Authors: Tags: News Features grad student Jason McLellan research RSV student profile Zika virus Source Type: news

Related Links:

(National University of Singapore) A multidisciplinary team of researchers at the National University of Singapore (NUS) has developed a portable, easy-to-use device for quick and accurate screening of diseases. This versatile technology platform called enVision (enzyme-assisted nanocomplexes for visual identification of nucleic acids) can be designed to detect a wide range of diseases - from emerging infectious diseases (e.g. Zika and Ebola) and high-prevalence infections (e.g. hepatitis, dengue, and malaria) to various types of cancers and genetic diseases.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
AbstractOver the past few decades, disease outbreaks have become increasingly frequent and widespread. The epicenters of these outbreaks have differed, and could be linked to different economic contexts. Arguably, the responses to these outbreaks have been “political” and inherently burdensome to marginalized populations. Key lessons can be learned from exploring the narratives about the different epidemics in varying income settings. Based on a review of the published medical, social, and political literature, which was accessed using four electr onic databases—PubMed, Sociological Abstracts, Scholars Po...
Source: Global Social Welfare - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 23 August 2018Source: Antiviral ResearchAuthor(s): Priya Luthra, Jacinth Naidoo, Colette A. Pietzsch, Sampriti De, Sudip Khadka, Manu Anantpadma, Caroline G. Williams, Megan R. Edwards, Robert A. Davey, Alexander Bukreyev, Joseph M. Ready, Christopher F. BaslerAbstractSpecific host pathways that may be targeted therapeutically to inhibit the replication of Ebola virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 compounds for inhibition of an EBOV minigenome (MG) assay that measures the function of the viral polymerase complex identified as hits sever...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Specific host pathways that may be targeted therapeutically to inhibit the replication of Ebola virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 compounds for inhibition of an EBOV minigenome (MG) assay that measures the function of the viral polymerase complex identified as hits several compounds with an amino-tetrahydrocarbazole scaffold. This scaffold was structurally similar to GSK983, a compound previously described as having broad-spectrum antiviral activity due to its impairing de novo pyrimidine biosynthesis through inhibition of dihydroorotate dehydrogenase...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
In this study, an arch-shaped amplification containing primer sequences was designed to rapidly amplify multiple targets. Further, the sensing platform allowed for sensitive and specific detection of human coronavirus, Middle East respiratory syndrome, Zika virus, and Ebola virus down to several copies. This platform also simultaneously distinguished between Middle East respiratory syndrome and human coronavirus in clinical specimens within 20 min. This arch-shaped multiple-target sensing assay can provide rapid, sensitive, and accurate diagnoses of emerging infectious diseases in clinical applications.
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
(MedPage Today) -- News and commentary from the world of infectious diseases
Source: MedPage Today Gastroenterology - Category: Gastroenterology Source Type: news
Despite many successes in the control of human infectious diseases they continue to pose a considerable risk to human health. Today, the rapid spatial spread of pathogens such as Ebola virus in West Africa, Yellow fever in Angola, and Zika in the Americas is unprecedented in their speed and magnitude. The main drivers are rapidly changing ecological and demographic processes. Traditionally, epidemiologists relied on passive disease case reporting and contact tracing data to inform and direct public health responses.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Type: Invited Presentation Source Type: research
Ebola. MERS. Zika. Nipah virus. Lassa fever. Rift Valley fever. All were in active outbreaks in June.
Source: Science - The Huffington Post - Category: Science Source Type: news
iva F Abstract Zika virus infection is associated with the development of severe neurological disorders in adults and newborns. Although at the moment Zika virus outbreak is not threatening to become again an emergency, infection cases are still being sporadically reported and there is still no effective therapy available. A possible treatment to suppress Zika replication is represented by short interfering RNAs (siRNAs), since they have been successfully used even against Ebola, H5N1 and SARS viruses and clinical trials of siRNA-based drugs are ongoing. In order to speed up the time consuming experimental validat...
Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research
Discussion and conclusionsDifferent techniques can be used to evaluate and measure innovative performance of countries. Country rankings published by traditional indexes, such as the Bloomberg Innovation Index (BII) and the Global Innovation Index (GII), only include high income economies among the top 20 performers. This is in sharp contrast to our approach, which identified 8-9 IDCs among the first 25 with China occupying the top position. Through an analysis of the pros and cons of the different methodologies, the IDC concept challenges more conventional approaches to address and estimate the innovative capacity of countries.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
More News: Ebola | Graduation | Hospital Management | Respiratory Medicine | Students | Universities & Medical Training | Zika Virus