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The Relationship Between Lesion Localization and Dysphagia in Acute Stroke

AbstractFactors that can facilitate early identification of individuals at risk of dysphagia such as stroke location are potentially of great benefit. The aim of this study was to examine the role of hemisphere and lesion location in assessing dysphagia pattern and airway invasion as identified through the use of validated, standardized interpretation measures for the videofluoroscopic swallowing study. Consecutive patients (N = 80) presenting with stroke symptoms who had a first-time acute ischemic stroke confirmed on diffusion-weighted magnetic resonance imaging (DW-MRI) scan participated. Three swallowing outcome variables were assessed using regression models: modified barium swallow impairment profile (MBSImP) ora l impairment (OI) and pharyngeal impairment (PI) scores and penetration aspiration scale (PAS) score. Subjects were primarily male and demonstrated mild stroke and mild to moderate dysphagia. There was a significantly higher likelihood of abnormal PAS scores for infratentorial lesions compared to ri ght hemisphere location (Odds ratio: 3.1, SE: 1.8,p = 0.046) and for Whites compared to African Americans (Odds ratio: 5.5, SE: 2.6,p = 
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Background and Purpose—Stroke imaging is pivotal for diagnosis and stratification of patients with acute ischemic stroke to treatment. The potential of combining multimodal information into reliable estimates of outcome learning calls for robust machine learning techniques with high flexibility and accuracy. We applied the novel extreme gradient boosting algorithm for multimodal magnetic resonance imaging–based infarct prediction.Methods—In a retrospective analysis of 195 patients with acute ischemic stroke, fluid-attenuated inversion recovery, diffusion-weighted imaging, and 10 perfusion parameters were ...
Source: Stroke - Category: Neurology Authors: Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Contributions Source Type: research
Abstract In vivo positron emission tomography (PET) imaging of nicotinic acetylcholine receptors (nAChRs) is a promising tool for the imaging evaluation of neurologic and neurodegenerative diseases. However, the role of α7 nAChRs after brain diseases such as cerebral ischemia and its involvement in inflammatory reaction is still largely unknown. In vivo and ex vivo evaluation of α7 nAChRs expression after transient middle cerebral artery occlusion (MCAO) was carried out using PET imaging with [11C]NS14492 and immunohistochemistry (IHC). Pharmacological activation of α7 receptors was evaluated with magneti...
Source: Glia - Category: Neurology Authors: Tags: RESEARCH ARTICLE Source Type: research
CONCLUSIONS: The data demonstrates the ability to combine MALD-MS with in vivo PET to image different aspects of stroke recovery. PMID: 29484723 [PubMed - as supplied by publisher]
Source: Rapid Communications in Mass Spectrometry : RCM - Category: Chemistry Authors: Tags: Rapid Commun Mass Spectrom Source Type: research
ABSTRACT BACKGROUND AND PURPOSEThe impact of blood‐brain barrier (BBB) disruption can be detected by intraparenchymal hyperdense lesion on the computed tomography (CT) scan after endovascular stroke therapy. The purpose of this study was to determine whether early BBB disruption predicts intracranial hemorrhage and poor outcome in patients with acute ischemic stroke treated with mechanical thrombectomy. METHODSWe analyzed patients with anterior circulation stroke treated with mechanical thrombectomy and identified BBB disruption on the noncontrast CT images immediately after endovascular treatment. Follow‐up CT or magn...
Source: Journal of Neuroimaging - Category: Radiology Authors: Tags: Clinical Investigative Study Source Type: research
Conclusions—The annual progression of carotid wall volume is independently associated with recurrent ischemic cerebrovascular events, and this measurement has added value for intraplaque hemorrhage and fibrous cap rupture in predicting future events.
Source: Stroke - Category: Neurology Authors: Tags: Clinical Studies, Magnetic Resonance Imaging (MRI), Atherosclerosis Original Contributions Source Type: research
Conclusions—Elevated hyperacute plasma F2-isoP concentrations independently predict the occurrence of IG and IG volume in patients with acute ischemic stroke. If validated in future studies, measuring plasma F2-isoP might be helpful in the acute setting to stratify patients with acute ischemic stroke for relative severity of ischemic injury and expected progression.
Source: Stroke - Category: Neurology Authors: Tags: Ischemic Stroke Original Contributions Source Type: research
Conclusions—Although a feature of small-vessel disease, PvS are not a predictor of cognitive decline, in contrast to lacunes. This study highlights the importance of carefully differentiating between lacunes and PvS in studies investigating vascular cognitive impairment.
Source: Stroke - Category: Neurology Authors: Tags: Aging, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
BackgroundThe major factor for the appropriate treatment strategies for ischemia patients is its onset timing. Purpose/HypothesisTo study to evaluate the diagnostic accuracy of T1 relaxation time in a rotating frame (T1ρ) and apparent diffusion coefficient (ADC) from MRI to estimate ischemia stages. Study TypeProspective. Population/Subjects/Phantom/Specimen/Animal ModelIn all, 73 patients (49 males, aged 29–78 years and 24 females, aged 22–94 years) with ischemia were prospectively imaged with T1ρ and diffusion MRI during the postischemic period. Field Strength/Sequence3T/T1ρ and diffusion‐weight...
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research
CONCLUSIONS: Elevated peak systolic BP during exercise is significantly related with WMLs, subclinical small vessel disease of brain, especially in normotensive subjects. PMID: 29308930 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Conclusions—Agreement between clinicians assessing DWI-ASPECTS and DWI-FLAIR mismatch may not be sufficient to make repeatable clinical decisions in mechanical thrombectomy. The dichotomization of the DWI-ASPECTS (0–5 versus 0–6 or 0–6 versus 7–10) improved interrater and intrarater agreement, however, its relevance for patients selection for mechanical thrombectomy needs to be validated in a randomized trial.
Source: Stroke - Category: Neurology Authors: Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke Brief Reports Source Type: research
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