Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians

Publication date: Available online 25 July 2017 Source:Mechanisms of Ageing and Development Author(s): C. Borrás, E. Serna, J. Gambini, M. Inglés, J. Vina Centenarians but not octogenarians up regulate the expression of miRNAs, as we previously reported. We have looked into miRNA biogenesis. We show that RNA POL II, DROSHA, EXPORTIN 5 and DICER, are up-regulated in centenarians compared with octogenarians. Furthermore, factors involved in the control of these miRNAs biogenesis genes are also up-regulated in centenarians. Therefore, the up-regulation of miRNA expression in centenarians can be explained in part because miRNA biogenesis pathway is depressed in octogenarians (ordinary aging) while it is maintained in centenarians (extraordinary aging).
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research