Antiproliferative Effects of Red and White Wine Extracts in PC-3 Prostate Cancer Cells
Does a history of androgen deprivation therapy contribute to falls and frailty in prostate cancer survivors?Journal of the American Geriatrics Society
Nigel Lewis-Baker, 71, from Effingham in Surrey, was told he had just months to live three years ago after being diagnosed with prostate cancer.
ConclusionAs PSMA-targeted agents become more widely disseminated, the patterns of uptake in structures that are not directly relevant to patients ’ cancers must be understood. This is the first systematic evaluation of the uptake of18F-DCFPyL in ganglia demonstrating a general trend with a descending frequency of radiotracer accumulation in lumbar, cervical, stellate, celiac, and sacral ganglia. The underlying biology that leads to variability of PSMA-targeted radiotracers in peripheral ganglia is not currently understood, but may provide opportunities for future research.
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...
ConclusionsUsing our scoring system, we can predict which patients with high-risk PCa would benefit more from RP. Thus, this system can be used in patient counseling to determine an optimal treatment strategy for high-risk PCa.
New, more effective antiandrogens are improving outcomes for men with newly diagnosed metastatic prostate cancer. The challenge is in choosing which to use, says Dr Chodak.Medscape Urology
New, more effective antiandrogens are improving outcomes for men with newly diagnosed metastatic prostate cancer. The challenge is in choosing which to use, says Dr Chodak.
ConclusionsWe demonstrated that RARP in the setting of oligometastatic PCa is a safe and feasible procedure and that it improves oncologic outcomes in terms of PFS and CSS. In addition, our data suggest that RARP effectively prevents urinary tract complications from PCa. However, our study highlights results from expert surgeons and highly selected patients that cannot be extrapolated to all patients with oligometastatic PCa. Therefore, to confirm our findings, large, prospective, multicenter studies are required.This article is protected by copyright. All rights reserved.
ConclusionOur short‐term safety, QoL and oncological control data demonstrate that focal IRE is a feasible salvage option for localized radio‐recurrent PCa. A prospective multi‐centre study (FIRE‐trial) has been initiated that will provide further insight in the ability of focal IRE to obtain oncological control of radio‐recurrent PCa with acceptable patient morbidity.This article is protected by copyright. All rights reserved.
ConclusionsPatients with limited nodal disease (1 –2 positive LNs) without adjuvant therapy showed favourable CSS-rates above 94% after 5 years. A subgroup of these patients (37%) remained metastasis-free without need of salvage treatment.