Pre-transplant Sensitization for Patient Awaiting Lung Transplant: Are We Concerned?

AbstractPurpose of ReviewThe goal of this paper is to highlight the changes in detection, management, and prognosis of pre-transplant sensitized candidates and recipients.Recent FindingsWith improvements in technology, human leukocyte antigen (HLA) antibody testing has identified a significant proportion of lung transplant candidates with pre-transplant HLA antibody detection. Pre-transplant antibodies are associated with worse early outcomes after lung transplant if not addressed with targeted antibody therapy. There are promising new therapy plans to address pre-transplant HLA antibodies and potentially ameliorate the early risk of antibody-mediated graft injury.SummaryPre-transplant sensitization continues to be a difficult problem in lung transplant. Detailed HLA antibody reports allow for precise identification of antibodies. The future challenge is how to manage these antibodies pre- and peri-transplant.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Authors: Ruszel N, Kubisa B, Lisowski P, Piotrowska M, Kubisa MJ, Brykczyński M, Wojtyś M, Pieróg J, Czarnecka M, Wójcik J, Wójcik N, Sielicki P, Bielewicz M, Grodzki T PMID: 31708987 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
Doctors at Henry Ford Health System in Detroit performed what they believe is the first double lung transplant in the US for a male patient whose lungs were irreparably damaged after vaping, according to the hospital.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
ConclusionWarm retrograde perfusion can remove more fat from lung grafts with fat embolism in a porcine donor model.
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Doctors at a Detroit hospital have performed a double lung transplant on a man whose lungs were damaged from vaping
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
AbstractPurpose of ReviewAlthough lung transplantation can be used to treat lung failure, limited donor organ availability creates a pressing need for improved artificial lung technology. This review discusses recent developments and future research pathways for respiratory assist devices and regenerative therapies intended to treat advanced lung disease.Recent FindingsHollow fiber membrane gas exchangers can be used to bridge lung failure patients to transplantation. Engineering improvements to such devices are on the verge of enabling longer term wearable systems that simplify and improve support. Progress with microchan...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
ConclusionIn immunosuppressed patients, FB and BAL should be evaluated early for clarifying the causative agents. Then, appropriate treatments can be utilized and the side effects and high cost of unnecessary treatment may be mitigated.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractPrimary graft dysfunction (PGD) is a rare complication associated with high mortality after heart transplantation, which may require veno-arterial extra-corporeal membrane oxygenation (VA-ECMO) support. A standardized definition for PGD was developed by the International Society of Heart and Lung Transplantation in 2014. Due to limited reports using this definition, the detailed outcomes after VA-ECMO support remain unclear. Therefore, we retrospectively analyzed our single-center outcomes of PGD following VA-ECMO support. Between September 2014 and August 2018, 160 patients underwent heart transplantation in our s...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research
Effects of bone marrow‑derived mesenchymal stem cell transplantation on chronic obstructive pulmonary disease/obstructive sleep apnea overlap syndrome in rats. Mol Med Rep. 2019 Sep 30;: Authors: Chen M, Huang Z, Bi H, Pan X, He J, He L, He X, Du J, Zhou K, Wang L, Wang Q, Guo X, Jin Z Abstract Bone marrow‑derived mesenchymal stem cells (BMSCs) possess potential therapeutic properties for treating patients with chronic obstructive pulmonary disease (COPD), which is characterized by emphysema and obstructive sleep apnea (OSA). However, their effects on overlap syndrome (OS) remain unclear. We invest...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Long-term post-transplant survival in Northern Spanish patients with CTD-ILD is reduced compared with IPF. PMID: 31694743 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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