Feasibility and safety of hyperthermic intraperitoneal chemotherapy using 5 ‐fluorouracil combined with cisplatin and mitomycin C in patients undergoing gastrectomy for advanced gastric cancer

ConclusionGastrectomy and HIPEC with MMC, CDDP, and 5‐FU is feasible, safe, and may protect against peritoneal metastasis following surgery for advanced GC.
Source: Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research

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Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsGastric cancer with peritoneal metastases was successfully treated with a combination of gastrectomy plus intraperitoneal and systemic chemotherapy. Further studies using this simplified approach may be indicated.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsGC patients with limited peritoneal metastases can benefit from CRS  + HIPEC. Hyperthermic intraperitoneal chemotherapy could be an effective method of adjuvant treatment of GC with a high risk of intraperitoneal progression. No long‐term survival may be expected after palliative approach to HIPEC.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Gastric cancer is the second leading cause of death from cancer worldwide. Consequently, prevention of peritoneal metastases after resection remains a substantial clinical need. Gastric cancer is more likely than other gastrointestinal malignant neoplasms to metastasize to peritoneal sites, and survival with peritoneal metastases is less than a year. Although systemic therapy for gastric cancer has improved, it has not prevented peritoneal dissemination. There has been interest in intraperitoneal approaches to preventing peritoneal dissemination since the 1980s. Hyperthermic intraperitoneal chemotherapy following radical g...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
ConclusionsWith short term follow-up, this patient’s outcome was favorable suggesting that surgical oncologic and bariatric procedures can be combined. Further, clinical investigations are indicated in this common clinical setting.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We report the first application of pressurized intraperitoneal aerosol chemotherapy (PIPAC) as a rescue therapy before palliative D2 gastrectomy combined with liver metastasectomy performed in a 49-year-old woman with peritoneal carcinomatosis who was primarily diagnosed with and underwent surgery for a Krukenberg tumor. The PIPAC procedure was performed with the use of cisplatin at 7.5 mg/m2 and doxorubicin at 1.5 mg/m2 for 30 min at 37 °C. Eight weeks after the PIPAC procedure, the patient underwent open classic D2 gastrectomy with the creation of a Roux-en-Y anastomosis (RNY) combined with liver metastasectomy. The ...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Conclusion: While still controversial, CRS followed by HIPEC may be a curative therapeutic option for highly selected patients.Case Rep Oncol 2018;11:305 –310
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Laparoscopic HIPEC was well tolerated, and an encouraging number of patients demonstrated an absence of peritoneal disease after HIPEC and were able to undergo gastrectomy. Comparative studies will be required to clarify survival benefits. PMID: 28799004 [PubMed - as supplied by publisher]
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: Ann Surg Oncol Source Type: research
Abstract BACKGROUND: The outcome of gastric cancer patients with peritoneal metastasis remains poor. We treated these patients with intraperitoneal and intravenous paclitaxel plus oral S-1 (tegafur/gimeracil/oteracil), followed by gastrectomy in responders. We evaluated the clinical significance of peritoneal lavage carcinoembryonic antigen (CEA) messenger RNA (mRNA) levels as a biomarker for indication of conversion gastrectomy. METHODS: The peritoneal lavage of 68 patients who received the above regimen as induction chemotherapy was repeatedly collected via intraperitoneal access ports. Gastrectomy was cons...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: Ann Surg Oncol Source Type: research
AbstractPeritoneal metastasis is common in gastric cancer. It is difficult to treat and carries a poor prognosis. Intraperitoneal (IP) delivery of chemotherapy can attain a higher drug exposure in the peritoneal cavity but with reduced systemic toxicity. Therefore, we hypothesized that IP paclitaxel with systemic chemotherapy would be clinically beneficial for gastric cancer with peritoneal metastases. Patients with unresectable and/or recurrent gastric adenocarcinoma with peritoneal dissemination and/or positive peritoneal washing cytology were recruited. They underwent eight cycles of IP paclitaxel and systemic XELOX. Th...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
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