Epigenetics insights into chronic pain: DNA hypomethylation in fibromyalgia—a controlled pilot-study

Abstract: To evaluate changes in DNA methylation profiles in patients with fibromyalgia (FM) compared to matched healthy controls (HCs). All individuals underwent full clinical and neurophysiological assessment by cortical excitability (CE) parameters measured by transcranial magnetic stimulation. DNA from the peripheral blood of patients with FM (n = 24) and HC (n = 24) were assessed using the Illumina-HumanMethylation450 BeadChips. We identified 1610 differentially methylated positions (DMPs) in patients with FM displaying a nonrandom distribution in regions of the genome. Sixty-nine percent of DMP in FM were hypomethylated compared to HC. Differentially methylated positions were enriched in 5 genomic regions (1p34; 6p21; 10q26; 17q25; 19q13). The functional characterization of 960 genes related to DMPs revealed an enrichment for MAPK signaling pathway (n = 18 genes), regulation of actin cytoskeleton (n = 15 genes), and focal adhesion (n = 13 genes). A gene–gene interaction network enrichment analysis revealed the participation of DNA repair pathways, mitochondria-related processes, and synaptic signaling. Even though DNA was extracted from peripheral blood, this set of genes was enriched for disorders such as schizophrenia, mood disorders, bulimia, hyperphagia, and obesity. Remarkably, the hierarchical clusterization based on the methylation levels of the 1610 DMPs showed an association with neurophysiological measurements of CE in FM and HC. Fibromyalgia has a hypom...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

Related Links:

CONCLUSIONS: Local application of sevoflurane in the wound bed appears to exhibit analgesic, antimicrobial, and positive healing effects. It could be a promising alternative treatment to be included as a therapeutic option for wound care. PMID: 31730517 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: The authors suggest stasis mucinosis and OALM represent the spectrum of euthyroid mucin depositional disease in varying clinical settings. PMID: 31730515 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Authors: Roshangar L, Soleimani Rad J, Kheirjou R, Reza Ranjkesh M, Ferdowsi Khosroshahi A Abstract Burn wounds are one of the main causes of skin damage. Based on World Health Organization statistics, almost 300 000 people worldwide die of burns each year. In severe burns, the cells and blood vessels are often injured and the blood supply to the wound is disturbed. Many factors such as oxygenation, infection, aging, hormones, and nutrition potentially can influence burn progression and disrupt repair with unbalanced release of various growth factors and cytokines. Different treatment approaches such as dressings a...
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Conclusions/interpretationThese results demonstrate a fundamental role for AIM2 in energy metabolism, inflammation and insulin resistance. Our studies establish a novel link between the innate immunity proteins, AIM2 and p202, and metabolism.
Source: Diabetologia - Category: Endocrinology Source Type: research
Date: Monday, 11 25, 2019; Speaker: Doug Chang, Thirst and water intake responses in obese and normal weight men, The Bogardus group, PECRB, NIDDK; Cuiying Xiao, Contribution of BRS3 in MC4R/SIM1 neurons to body weight/termperature in mice, The Reitman group, DEOB, NIDDK; Building: Building 10 (Clinical Center); Solarium Conference Room 9S233 (old Bunim Room)
Source: NIH Calendar of Events - Category: American Health Source Type: events
This study is helpful to evaluate the properties of graphene in an oxygen-rich environment. At the same time, it has certain significance for the application of graphene in band gap engineering.
Source: Physica E: Low dimensional Systems and Nanostructures - Category: Nanotechnology Source Type: research
Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Vahid Zarghami, Mohammad Ghorbani, Kamran Pooshang Bagheri, Mohammad Ali ShokrgozarAbstractBioactive glass has been used clinically in bone repair applications for bone grafting because of its prominent physiochemical and osteogenic properties. Various attempts have been made to enhance bioactive glass efficiency in combination with other biomaterials such as antibiotics and growth factors. In present study, we developed a modification of bioactive glass nanoparticles that insured long term antibacterial effect. Bioactive glass n...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
CONCLUSIONS: This outbreak highlighted communication failures, from hunters to consumers. Awareness should be raised on the relation between trichinellosis and game meat. Trichinella species detection is important for adequate outbreak recording and could contribute to better understanding the clinical and serological signs of T. britovi infection. PMID: 31732242 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Women with schizophrenia are only half as likely as women in the general population to receive mammograms, reports ameta-analysis published inPsychiatric Services in Advance.“Lower screening rates could explain why women with schizophrenia and other serious mental illnesses are found to have more advanced breast cancer at time of diagnosis,” wrote Alison Hwong, M.D., Ph.D., and colleagues at the University of California, San Francisco. “Given the high prevalence o f breast cancer and the promising prognosis of breast cancer if detected early, mammography screening is a key first step in improving diagnosi...
Source: Psychiatr News - Category: Psychiatry Tags: Alison Hwong breast cancer cancer screening mammogram meta-analysis preventive service Psychiatric Services in Advance psychotic disorders schizophrenia Source Type: research
"We believe that one of the drivers of the obesity epidemic is ready access to energy dense, hyperpalatable foods," says an expert. Having a standard, universal definition is therefore key.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
More News: Anesthesiology | Brain | Bulimia | Chronic Pain | Eating Disorders & Weight Management | Fibromyalgia | Gastroschisis Repair | Genetics | Mitochondria | Neurology | Obesity | Pain | Schizophrenia | Study