Measles Vaccine Study Findings a'Wake-up Call'Measles Vaccine Study Findings a'Wake-up Call '

Further declines in measles vaccine coverage could make the disease endemic again in the United States, the authors warn.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pediatrics News Source Type: news

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Abstract BACKGROUND: Measles incidence in the 53 Member States of the World Health Organization (WHO) European Region has fallen dramatically in recent decades. The European Regional Verification Commission for Measles and Rubella Elimination (RVC) verified that 43 member states had interrupted endemic measles transmission for ≥12 months by the end of 2017. However, measles incidence in the region increased sharply in 2018 compared to 2017. The purpose of this article is to assess the current status of measles in the Region in relation to its elimination goal. It also discusses challenges and act...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - Category: International Medicine & Public Health Authors: Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
In this study, we aimed to update the estimations of case-fatality ratios for measles, to develop a prediction model to estimate case-fatality ratios across heterogeneous groupings, and to project future case-fatality ratios for measles up to 2030.MethodsWe did a review of the literature to identify studies examining measles cases and deaths in low-income and middle-income countries in all age groups from 1980 to 2016. We extracted data on case-fatality ratios for measles overall and by age, where possible. We developed and examined several types of generalised linear models and determined the best-fit model according to t...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Conclusions and significanceOur findings suggest thatS.mansoni infection among pre-school children is associated with a reduced antibody response to catch-up measles immunisation, and that praziquantel treatment improves the response.S.mansoni infection may contribute to impaired vaccine responses in endemic populations; effective schistosomiasis control may be beneficial for vaccine efficacy. This should be further explored. Trial registrationISRCTN87107592.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Purpose: The measles virus circulation was halted in Brazil in 2001 and the country has a routine vaccination coverage against measles, mumps and rubella higher than 95%. In Cear á, the last confirmed case was in 1999. This abstract describes the strategies adopted and the effectiveness of the surveillance and control measures implemented during the epidemic in an attempt to understand the challenges posed by the regional context of post-measles elimination and explain the actions taken to prevent the re-establishment of endemic transmission when the virus is imported.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.100 Source Type: research
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract In the Netherlands there has been nationwide vaccination against the measles since 1977. However, a tight-knit community of a few hundred thousand orthodox protestants in the "Dutch Bible Belt" refuses the vaccine. Within this community of orthodox protestants there has been an outbreak of the measles with roughly 2500 reported cases about every twelve years. Each outbreak has lasted about a year. The community of orthodox protestants is too small to permanently keep the virus in circulation and have the infection be endemic. The dynamics in orthodox-protestant schools has been widely recognized...
Source: Biosystems - Category: Biotechnology Authors: Tags: Biosystems Source Type: research
Nogueira PJ Abstract In Portugal, measles vaccination coverage and population immunity are high, and no endemic measles cases had been reported since 2004. The World Health Organization classified measles as eliminated in the country in 2015 and 2016, based on data from the previous 3 years. However, in a context of increasing incidence in several European countries in 2016 and 2017, Portugal experienced two simultaneous measles outbreaks with a total of 27 laboratory-confirmed cases (0.3 cases/100,000 population) in two health regions between February and May 2017. Nineteen cases (70.1%) were adults, of whom 12 w...
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research
Abstract We investigate an SIR epidemic model with discrete age groups to understand the transmission dynamics of an infectious disease in a host population with an age structure. We derive the basic reproduction number R0 and show that it is a sharp threshold parameter. If R0≤1, the disease-free equilibrium E0 is globally stable. If R0>1,E0 is unstable, the model is uniformly persistent, and an endemic equilibrium exists. The global stability of the endemic equilibrium when R0>1 is established under a sufficient condition. The model is then used to analyze the measles data in India and evaluate the effec...
Source: Mathematical Biosciences - Category: Statistics Authors: Tags: Math Biosci Source Type: research
AbstractMeasles outbreaks were recently reported in Europe due to low immunization rates. In this scenario, identifying the reasons of no vaccination is crucial to set up strategies to improve immunization rate. A cross-sectional study was conducted to investigate the determinants of missed vaccination in children living in Southern Italy, during the 2016 outbreak. A standardized face-to-face questionnaire was used to record demographic data, immunization status, and reasons for missed vaccination. A total of 1141 children (median age 86  months, male 47.2%) was enrolled, 77.8% of the children were adequately vaccinat...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
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