Brain responses to vestibular pain and its anticipation in women with genito-pelvic pain/penetration disorder

Conclusions Women with GPPPD are characterized by increased subjective and brain responses to vestibular pain and, to a lesser extent, its anticipation, with fear and anxiety associated with responses to pain, supporting the introduction of anticipatory fear as a criterion of GPPPD in DSM-5. Abbreviations Image 1 aMCC anterior midcingulate cortex dlPFC dorsolateral prefrontal cortex DSM-5 Diagnostic Statistical Manual of Mental Disorders, fifth edition FM fibromyalgia fMRI functional magnetic resonance imaging FPQ Fear of Pain Questionnaire GPPPD Genito-Pelvic Pain/Penetration Disorder HC healthy controls IBS irritable bowel syndrome n number OFC orbitofrontal cortex pACC perigenual anterior cingulate cortex PASS Pain Anxiety Symptoms Scale PVD provoked vestibulodynia Q1 Quartile 1 Q3 Quartile 3 SAS statistical analysis software SD standard deviation SII secondary somatosensory cortex SMA supplementary motor area SPM8 Statistical Parametric Mapping, SPM8 SPSS Statistical Package for Social Sciences STAI State-Trait Anxiety Inventory TR/TE repetition time/echo time VAS Visual Analogue Scale vlPFC ventrolateral prefrontal cortex vmPFC ventromedial prefrontal cortex

Source: NeuroImage: Clinical - July 25, 2017 Category: Radiology Source Type: research