Maiden Voyage of the Collaborative Cross Mouse: Exploring Variability in Animals ’ Response to Perchloroethylene

PDF Version (742 KB) About This Article Published: 24 July 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population Joseph A. Cichocki, Shinji Furuya, Abhishek Venkatratnam, Thomas J. McDonald, Anthony H. Knap, Terry Wade, Stephen Sweet, Weihsueh A. Chiu, David W. Threadgill, and Ivan Rusyn Researchers have spent more than a decade perfecting an alternative laboratory mouse model—the Collaborative Cross (CC)—that is designed to mimic the genetic diversity of the human population.1 This issue of Environmental Health Perspectives contains the first published toxicology study to be performed with CC mice: an exploration of how the toxic effects of perchloroethylene vary from animal to animal.2 Most inbred mouse strains are genetically identical, which means that individuals from the same strain respond similarly to the same chemical exposure. This limits researchers’ ability to study ho...
Source: EHP Research - Category: Environmental Health Authors: Tags: Science Selection Source Type: research