Increased blood cadmium levels were not associated with increased fracture risk but with increased total mortality in women: the Malm ö Diet and Cancer Study

This study aimed to investigate if high levels of blood cadmium at baseline were associated with increased fracture risk during follow-up in middle-aged women. No increased fracture risk was observed during follow-up, but women with higher levels of cadmium had an increased overall mortality.IntroductionExposure to high levels ofcadmium has been associated with an increased fracture risk. The aim was to investigate a perceived association between low levels of blood cadmium (B-Cd) at baseline and risk of first incident fracture.MethodsFrom the population-based Malm ö Diet and Cancer Study Cardiovascular cohort, 2920 middle-aged women with available background questionnaire and B-Cd measurements were included. Women were divided into quartiles (Q) according to their cadmium levels (Cd-Q10.51  μg/L). National registries were analysed for prospective risk of fractures or death. Associations between B-Cd and fracture risk were assessed by survival analysis (Cox regression analysis).ResultsIn total, 998 first incident fractures occurred in women during a follow-up lasting 20.2  years (median) (12.5–21.2 years) (25th–75th percentile). Women in Cd-Q4 were more often current smokers than in Cd-Q1 78.4 vs. 3.3% (p 
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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In this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors.The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)2}]. The structures of all mixes were completely portrayed by spectroscopic techniques (1H-NMR, 13C{1H} NMR , IR and elemental and further analyzed by DFT/...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
CONCLUSION: PSs represent a potential tool to treat this form of breast cancer by providing peptides that may be useful in therapy. PMID: 32065785 [PubMed - in process]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
Publication date: Available online 17 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Hombaiah Chandana, B. Madhu, M.R. Narayana MurthyAbstractIntroductionGlobally, cervical cancer is the 4th most common cancer and is one of the leading cancers causing death in India. Cervical cancer is one of those cancers which can be easily prevented by screening women who are aged above 30 years and by vaccinating young girls against HPV. Lack of awareness about cervical cancer makes early detection and timely screening difficult. Awareness about cervical cancer among people will help us to decide on an appropria...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
ConclusionsOur findings support measurement invariance of the EORTC QLQ-C30 in a large sample of patients with hematological malignancies. The results showed that the number of non-invariant items was negligible, suggesting that this questionnaire is a valid and robust measurement tool in patients with hematological malignancies, also for comparisons across groups and time.
Source: Quality of Life Research - Category: Health Management Source Type: research
Publication date: Available online 17 February 2020Source: European Journal of Surgical OncologyAuthor(s): Jingdong Li, Yaxuan Wang, Xueliang Chang, Zhenwei HanAbstractPurposeTo evaluate the efficacy and safety of laparoscopic adrenalectomy (LA) vs open adrenalectomy (OA) for pheochromocytoma (PHEO).MethodsA systematic literature research of PubMed, Ovid, Scopus, and citation lists were performed to identify eligible studies. All studies comparing LA versus OA for PHEO were included.ResultsOverall, fourteen studies including 743 patients (LA 391; OA 352) were included. LA might have smaller tumor size (WMD -0.92 cm, 95% CI -1.09 to -0.76; p
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsCaffeine was a marker for increased intake of calories and decreased intake of key nutrients. When discussing dietary intake in early childhood, practitioners should screen for nutrient deficiency in young children and recommend limiting the intake of caffeinated foods and beverages.
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Hongying Wang, Weiping TianAbstractMicroRNAs (miRNAs) have been proven to be critical regulators of cancer development. To date, many of them are still in urgent need of characterisation, and role of miR-595 in hepatocellular carcinoma (HCC) remains unknown. To better understand the mechanism of miR-595 in HCC development, a series of experiments were carried out to explore the effects of miR-595 on malignant behaviour in HCC. First, we found that miR-595 was downregulated in HCC tissues and cells and tightly associated w...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Bolin Wang, Zhong Lu, Yan Huang, Tao LinAbstractPurposeNumerous studies have reported the prognostic role of lncRNA-ATB high expression in solid tumours, but its prognostic effect is still uncertain. Therefore, the purpose of this meta-analysis was to further comprehensively verify the prognostic role of the lncRNA-ATB high expression in solid tumours.MethodsA literature search was performed using the electronic platforms to obtain relevant research studies published up to 31 May 2019. Confidence intervals of research end...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Sug Hyung Lee
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsMechanisms connecting depression to physical illness appear to involve alterations in the hypothalamic‐pituitary axis, unhealthy lifestyle, chronic or acute stressors including posttraumatic stress, an increase in C‐reactive protein (CRP) in men, taking antidepressant medication, and social and emotional loneliness. Clinical RelevanceA good patient–provider relationship can help to promote decreased acute or chronic stressors, increased family and social support, decreased loneliness, modification of unhealthy lifestyles such as smoking, obesity, physical inactivity, alcohol, control of CRP, and antide...
Source: Journal of Nursing Scholarship - Category: Nursing Authors: Tags: CLINICAL SCHOLARSHIP Source Type: research
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