Association between bone mineral density, muscle strength, and vitamin D status in patients with myasthenia gravis: a cross-sectional study

AbstractSummaryMyasthenia gravis (MG) patients had low proximal hip BMD, which could be explained by reduced muscle strength, elevated bone resorption markers, vitamin D deficiency, and increased PTH levels in those with MG compared to controls.IntroductionMuscle strength is closely correlated with bone mineral density (BMD) and vitamin D status. Here, we evaluated muscle strength, BMD, and vitamin D status in a large sample of Chinese patients with MG.MethodsIn this cross-sectional survey, 86 patients with MG without glucocorticoid treatment and 86 healthy controls were included. Serum levels of 25-hydroxyvitamin D [25OHD], parathyroid hormone (PTH), bone turnover markers (BTMs), and BMD were measured and compared between the two groups. Grip strength and one-leg standing time (OLST) were also assessed in MG patients.ResultsLow grip strength and short OLST were found in 11 (12.8%) and 12 (14.0%) MG patients, respectively. There were 3 (3.5%) MG patients with low bone mass for chronological age. Serum beta C-terminal telopeptide and PTH levels were higher (p 
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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ABSTRACTX ‐linked hypophosphatemia (XLH) is characterized by increased activity of circulating FGF23 resulting in renal phosphate wasting and abnormal bone mineralization. Hyperparathyroidism may develop in XLH patients; however its prevalence, pathogenesis and clinical presentation are not documented.This observational study (CNIL 2171036 v 0) recruited XLH adult patients in a single tertiary referral center. Each patient was explored in standardized conditions and compared with two healthy volunteers, matched for sex, age and 25 ‐OH vitamin D concentrations. The primary endpoint was the proportion of patients with hy...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
In conclusion, implementation of FLS was associated with a reduced risk of recurrent fracture, indicating that FLSs should be included routinely at hospitals treating fracture patients.This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
ABSTRACTThe loss of estrogen (E2) initiates a rapid phase of bone loss leading to osteoporosis in one ‐half of postmenopausal women, but the mechanism is not fully understood. Here, we show for the first time how loss of E2 activates low ‐grade inflammation to promote the acute phase of bone catabolic activity in ovariectomized (OVX) mice. E2 regulates the abundance of dendritic cells (DCs) that express IL ‐7 and IL‐15 by inducing the Fas ligand (FasL) and apoptosis of the DC. In the absence of E2, DCs become long ‐lived, leading to increased IL‐7 and IL‐15. We find that IL‐7 and IL‐15 together, but not a...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Direct oral anticoagulants (DOACs) are increasingly being used in the elderly population in view of its ease of use, efficacy, and favorable side ‐effect profile compared with the vitamin K antagonists. However, there is a need for increase awareness of well‐characterized cases, albeit a small number, of bullous pemphigoid‐like skin reactions associated with rivaroxaban. AbstractDirect oral anticoagulants (DOACs) are increasingly being used in the elderly population in view of its ease of use, efficacy, and favorable side ‐effect profile compared with the vitamin K antagonists. However, there is a need for increase...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
Hopes the coronavirus would be contained to China vanished on Friday as infections spread rapidly around the world, countries started stockpiling medical equipment and investors took flight in expectation of a global recession.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
A new virus that emerged in China has infected more than 83,000 people and caused more than 2,800 deaths
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
You're reading How To Flourish Financially with Forgiveness Practice, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Many people are looking for ways to improve their finances. It’s a hot topic and there are a lot of great concepts out there. I’d like to share a soul-oriented perspective on your financial condition and how to improve it. My spiritual teacher, Dr. and Master Zhi Gang Sha, teaches that the soul is the boss in life and that everything happens at the soul level first. Soul is information. You...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured philosophy success finance forgiveness practice money ritual Source Type: blogs
Iran said on Thursday its death toll from coronavirus had risen to 26, by far the highest number outside China, and the total number of infected people now stood at 245, including several senior officials.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Authors: Micali G, Verzì AE, Giuffrida G, Panebianco E, Musumeci ML, Lacarrubba F Abstract Inverse psoriasis represents a clinical variant of psoriasis that is sometimes difficult to diagnose due to its clinical similarity with other skin disorders involving the folds, mainly including mechanical intertrigo, fungal and bacterial infections, contact dermatitis, seborrheic dermatitis, and lichen planus. Dermoscopy represents a useful tool for an enhanced non-invasive diagnosis. The treatment of inverse psoriasis may be challenging and include topical corticosteroids, topical calcineurin inhibitors, vitamin D a...
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
ConclusionApplication of the BDDCS to predict interactions between rifampin and antihypertensive drugs for patients with both tuberculosis and hypertension was found to be reliable. It should be noted, however, that based on the CYP enzyme and drug transporter information we reviewed, the mechanisms of all of the interactions could not be elucidated, and the predictions are only based on theory. The real effects of rifampin on antihypertensive drugs need to be further observed. Further studies in both animals and humans are needed in the future.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
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